Deep learning approaches for natural product discovery from plant endophytic microbiomes

SA Aghdam, AMV Brown - Environmental microbiome, 2021 - Springer
Plant microbiomes are not only diverse, but also appear to host a vast pool of secondary
metabolites holding great promise for bioactive natural products and drug discovery. Yet …

[HTML][HTML] Genome mining for antimicrobial compounds in wild marine animals-associated enterococci

J Prichula, M Primon-Barros, RCZ Luz, ÍMS Castro… - Marine Drugs, 2021 - mdpi.com
New ecosystems are being actively mined for new bioactive compounds. Because of the
large amount of unexplored biodiversity, bacteria from marine environments are especially …

Tradeoffs Between Evolved Phage Resistance and Antibiotic Susceptibility in a Highly Drug-Resistant Cystic Fibrosis-Derived Pseudomonas aeruginosa Strain

K Wilburn, CB Matrishin, A Choudhury, R Larsen… - PHAGE, 2024 - liebertpub.com
Background: Multi-drug resistant pathogens pose significant challenges towards the
effective resolution of bacterial infections. A promising alternative strategy is phage therapy …

Characterization of Pseudomonas Strains Isolated from Lake Superior that Inhibit Cystic Fibrosis Derived Pathogens

T Lenoy - 2024 - rave.ohiolink.edu
The overuse and misuse of antibiotics has led to a global crisis in which most bacterial
pathogens have evolved resistance to the available drugs used for treatments. As a result …

[КНИГА][B] Isolation and Characterizing of Environmental Bacteria that Inhibit Multi-Drug Resistant Pathogens

J Adesanya - 2023 - search.proquest.com
Bacterial pathogens are evolving resistance to all available antibiotics and are a leading
cause of death worldwide. Thus, the discovery of new antibiotics that inhibit multi-drug …

[КНИГА][B] Utilizing Bacteriophage to Evolve Antibiotic Susceptibility in Multidrug-Resistant Pseudomonas aeruginosa.

AN Choudhury - 2021 - search.proquest.com
Pharmaceutical companies have slowed the discovery and development of antibiotics due
to low-profit margins. Therefore, antibiotic discovery is at an all-time low, and pathogens …

Identifying Gene Regions That Produce Antagonistic Factors Against Multidrug Resistant Pathogens

RA Crowl - 2021 - rave.ohiolink.edu
Multidrug resistant (MDR) bacterial infections cause an estimated 700,000 deaths per year
worldwide. By the year 2050, it is predicted that MDR infections will account for 10 million …

[КНИГА][B] Identification of broad host range phage that antagonize multidrug resistant Pseudomonas aeruginosa and their therapeutic potential to restore antibiotic …

AE Lake - 2020 - search.proquest.com
Multidrug resistant (MDR) pathogens are predicted to cause more than ten million annual
deaths worldwide by 2050, making bacterial infections the leading cause of death. Although …

Isolation and Characterization of Broad Host Range Phage that infect P. aeruginosa Pathogens

KM Wilburn - 2020 - rave.ohiolink.edu
The CDC predicts that 10 million deaths will occur worldwide by 2050 due to multi-drug
resistant (MDR) bacterial infections. As microbial resistance increases, the number of new …

Caracterización bioinformática de la vía de Sintetasa de péptidos no ribosomales encontrada en el genoma de Pseudomonas koreensis I1 que muestra similitud con …

JL Geney Higuita - 2021 - repositorio.uchile.cl
El antagonismo bacteriano es una fuente importante de productos naturales de relevancia
biotecnológica. Las moléculas caracterizadas involucradas en este fenómeno son …