Function and therapeutic value of astrocytes in neurological diseases
Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …
Astrocyte crosstalk in CNS inflammation
Astrocytes control multiple processes in the nervous system in health and disease. It is now
clear that specific astrocyte subsets or activation states are associated with specific genomic …
clear that specific astrocyte subsets or activation states are associated with specific genomic …
Molecular basis of astrocyte diversity and morphology across the CNS in health and disease
Astrocytes, a type of glia, are abundant and morphologically complex cells. Here, we report
astrocyte molecular profiles, diversity, and morphology across the mouse central nervous …
astrocyte molecular profiles, diversity, and morphology across the mouse central nervous …
Astrocyte reactivity: subtypes, states, and functions in CNS innate immunity
MV Sofroniew - Trends in immunology, 2020 - cell.com
Astrocytes are neural parenchymal cells that ubiquitously tile the central nervous system
(CNS). In addition to playing essential roles in healthy tissue, astrocytes exhibit an …
(CNS). In addition to playing essential roles in healthy tissue, astrocytes exhibit an …
Normal aging induces A1-like astrocyte reactivity
LE Clarke, SA Liddelow… - Proceedings of the …, 2018 - National Acad Sciences
The decline of cognitive function occurs with aging, but the mechanisms responsible are
unknown. Astrocytes instruct the formation, maturation, and elimination of synapses, and …
unknown. Astrocytes instruct the formation, maturation, and elimination of synapses, and …
[HTML][HTML] Microglial remodeling of the extracellular matrix promotes synapse plasticity
Synapse remodeling is essential to encode experiences into neuronal circuits. Here, we
define a molecular interaction between neurons and microglia that drives experience …
define a molecular interaction between neurons and microglia that drives experience …
The role of astrocytes in CNS inflammation
Astrocytes are the most abundant cell type in the central nervous system (CNS), performing
complex functions in health and disease. It is now clear that multiple astrocyte subsets or …
complex functions in health and disease. It is now clear that multiple astrocyte subsets or …
[HTML][HTML] Cell biology of astrocyte-synapse interactions
Astrocytes, the most abundant glial cells in the mammalian brain, are critical regulators of
brain development and physiology through dynamic and often bidirectional interactions with …
brain development and physiology through dynamic and often bidirectional interactions with …
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor
Astrocytes have important roles in the central nervous system (CNS) during health and
disease. Through genome-wide analyses we detected a transcriptional response to type I …
disease. Through genome-wide analyses we detected a transcriptional response to type I …
Diversity of astrocyte functions and phenotypes in neural circuits
BS Khakh, MV Sofroniew - Nature neuroscience, 2015 - nature.com
Astrocytes tile the entire CNS. They are vital for neural circuit function, but have traditionally
been viewed as simple, homogenous cells that serve the same essential supportive roles …
been viewed as simple, homogenous cells that serve the same essential supportive roles …