Function and therapeutic value of astrocytes in neurological diseases

HG Lee, MA Wheeler, FJ Quintana - Nature reviews Drug discovery, 2022 - nature.com
Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …

Astrocyte crosstalk in CNS inflammation

M Linnerbauer, MA Wheeler, FJ Quintana - Neuron, 2020 - cell.com
Astrocytes control multiple processes in the nervous system in health and disease. It is now
clear that specific astrocyte subsets or activation states are associated with specific genomic …

Molecular basis of astrocyte diversity and morphology across the CNS in health and disease

F Endo, A Kasai, JS Soto, X Yu, Z Qu, H Hashimoto… - Science, 2022 - science.org
Astrocytes, a type of glia, are abundant and morphologically complex cells. Here, we report
astrocyte molecular profiles, diversity, and morphology across the mouse central nervous …

Astrocyte reactivity: subtypes, states, and functions in CNS innate immunity

MV Sofroniew - Trends in immunology, 2020 - cell.com
Astrocytes are neural parenchymal cells that ubiquitously tile the central nervous system
(CNS). In addition to playing essential roles in healthy tissue, astrocytes exhibit an …

Normal aging induces A1-like astrocyte reactivity

LE Clarke, SA Liddelow… - Proceedings of the …, 2018 - National Acad Sciences
The decline of cognitive function occurs with aging, but the mechanisms responsible are
unknown. Astrocytes instruct the formation, maturation, and elimination of synapses, and …

[HTML][HTML] Microglial remodeling of the extracellular matrix promotes synapse plasticity

PT Nguyen, LC Dorman, S Pan, ID Vainchtein, RT Han… - Cell, 2020 - cell.com
Synapse remodeling is essential to encode experiences into neuronal circuits. Here, we
define a molecular interaction between neurons and microglia that drives experience …

The role of astrocytes in CNS inflammation

F Giovannoni, FJ Quintana - Trends in immunology, 2020 - cell.com
Astrocytes are the most abundant cell type in the central nervous system (CNS), performing
complex functions in health and disease. It is now clear that multiple astrocyte subsets or …

[HTML][HTML] Cell biology of astrocyte-synapse interactions

NJ Allen, C Eroglu - Neuron, 2017 - cell.com
Astrocytes, the most abundant glial cells in the mammalian brain, are critical regulators of
brain development and physiology through dynamic and often bidirectional interactions with …

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

V Rothhammer, ID Mascanfroni, L Bunse… - Nature medicine, 2016 - nature.com
Astrocytes have important roles in the central nervous system (CNS) during health and
disease. Through genome-wide analyses we detected a transcriptional response to type I …

Diversity of astrocyte functions and phenotypes in neural circuits

BS Khakh, MV Sofroniew - Nature neuroscience, 2015 - nature.com
Astrocytes tile the entire CNS. They are vital for neural circuit function, but have traditionally
been viewed as simple, homogenous cells that serve the same essential supportive roles …