A guide to current methodology and usage of reverse vaccinology towards in silico vaccine discovery

SJ Goodswen, PJ Kennedy… - FEMS Microbiology …, 2023 - academic.oup.com
Reverse vaccinology (RV) was described at its inception in 2000 as an in silico process that
starts from the genomic sequence of the pathogen and ends with a list of potential protein …

In silico design and immunoinformatics analysis of a universal multi-epitope vaccine against monkeypox virus

S Sanami, S Nazarian, S Ahmad, E Raeisi… - Plos one, 2023 - journals.plos.org
Monkeypox virus (MPXV) outbreaks have been reported in various countries worldwide;
however, there is no specific vaccine against MPXV. In this study, therefore, we employed …

Immunoinformatics design of a structural proteins driven multi-epitope candidate vaccine against different SARS-CoV-2 variants based on fynomer

J Sarvmeili, B Baghban Kohnehrouz, A Gholizadeh… - Scientific Reports, 2024 - nature.com
The ideal vaccines for combating diseases that may emerge in the future require more than
simply inactivating a few pathogenic strains. This study aims to provide a peptide-based …

Designing a novel multi‑epitope vaccine against Ebola virus using reverse vaccinology approach

M Alizadeh, H Amini-Khoei, S Tahmasebian… - Scientific reports, 2022 - nature.com
Ebola virus (EBOV) is a dangerous zoonotic infectious disease. To date, more than 25 EBOV
outbreaks have been documented, the majority of which have occurred in Central Africa …

Contriving multi-epitope vaccine ensemble for monkeypox disease using an immunoinformatics approach

S Aziz, FN Almajhdi, M Waqas, I Ullah… - Frontiers in …, 2022 - frontiersin.org
The current global outbreak of monkeypox (MPX) disease, caused by Monkeypox virus
(MPXV), has resulted in 16 thousand infection cases, five deaths, and has been declared a …

Immunoinformatics-guided approach for designing a pan-proteome multi-epitope subunit vaccine against African swine fever virus

AM Simbulan, EC Banico, EMJS Sira… - Scientific Reports, 2024 - nature.com
Despite being identified over a hundred years ago, there is still no commercially available
vaccine for the highly contagious and deadly African swine fever virus (ASFV). This study …

[HTML][HTML] Isolation, characterization and pharmacological potentials of methanol extract of Cassia fistula leaves: evidenced from mice model along with molecular …

MA Taher, AA Laboni, MA Islam, H Hasnat, MM Hasan… - Heliyon, 2024 - cell.com
The purpose of the current investigation was to conduct a detailed analysis of the chemical
components and medicinal properties of the methanolic crude extract derived from the …

[HTML][HTML] Bioactive compounds extracted from leaves of G. cyanocarpa using various solvents in chromatographic separation showed anti-cancer and anti-microbial …

MA TAHER, AA LABONI, SA SHOMPA… - Chinese Journal of …, 2023 - Elsevier
The study was carried out to determine the possible bioactive compounds from Ethanol,
Methanol, Petroleum ether, and Dichloromethane fractions of Glycosmic cyanocarpa (G …

Predicting TCR sequences for unseen antigen epitopes using structural and sequence features

H Ji, XX Wang, Q Zhang, C Zhang… - Briefings in …, 2024 - academic.oup.com
T-cell receptor (TCR) recognition of antigens is fundamental to the adaptive immune
response. With the expansion of experimental techniques, a substantial database of …

[HTML][HTML] Development of an ancestral DC and TLR4-inducing multi-epitope peptide vaccine against the spike protein of SARS-CoV and SARS-CoV-2 using the …

C Aram, P Alijanizadeh, K Saleki, L Karami - Biochemistry and Biophysics …, 2024 - Elsevier
The oldest human coronavirus that started pandemics is severe acute respiratory syndrome
virus (SARS-CoV). While SARS-CoV was eradicated, its new version, SARS-CoV2, caused …