The long and short non-coding RNAs modulating EZH2 signaling in cancer
Non-coding RNAs (ncRNAs) are a large family of RNA molecules with no capability in
encoding proteins. However, they participate in developmental and biological processes …
encoding proteins. However, they participate in developmental and biological processes …
[HTML][HTML] Bevacizumab (Avastin®) in cancer treatment: A review of 15 years of clinical experience and future outlook
J Garcia, HI Hurwitz, AB Sandler, D Miles… - Cancer treatment …, 2020 - Elsevier
When the VEGF-A-targeting monoclonal antibody bevacizumab (Avastin®) entered clinical
practice more than 15 years ago, it was one of the first targeted therapies and the first …
practice more than 15 years ago, it was one of the first targeted therapies and the first …
Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers
The incidence of aggressive neuroendocrine prostate cancers (NEPC) related to androgen-
deprivation therapy (ADT) is rising. NEPC is still poorly understood, such as its …
deprivation therapy (ADT) is rising. NEPC is still poorly understood, such as its …
PRAME as an independent biomarker for metastasis in uveal melanoma
Purpose: Uveal melanoma (UM) can be classified by gene expression profiling (GEP) into
Class 1 (low metastatic risk) and Class 2 (high metastatic risk), the latter being strongly …
Class 1 (low metastatic risk) and Class 2 (high metastatic risk), the latter being strongly …
Genomics-driven oncology: framework for an emerging paradigm
LA Garraway - Journal of Clinical Oncology, 2013 - ascopubs.org
A majority of cancers are driven by genomic alterations that dysregulate key oncogenic
pathways influencing cell growth and survival. However, the ability to harness tumor genetic …
pathways influencing cell growth and survival. However, the ability to harness tumor genetic …
Long noncoding RNAs: emerging stars in gene regulation, epigenetics and human disease
A Bhan, SS Mandal - ChemMedChem, 2014 - Wiley Online Library
Noncoding RNAs (ncRNAs) are classes of transcripts that are encoded by the genome and
transcribed but never get translated into proteins. Though not translated into proteins …
transcribed but never get translated into proteins. Though not translated into proteins …
EZH2 inhibitor GSK126 suppresses antitumor immunity by driving production of myeloid-derived suppressor cells
S Huang, Z Wang, J Zhou, J Huang, L Zhou, J Luo… - Cancer Research, 2019 - AACR
Enhancer of zeste homolog (EZH2) is a key epigenetic regulator of gene expression and is
frequently overexpressed in various cancer types, suggesting a role in oncogenesis. The …
frequently overexpressed in various cancer types, suggesting a role in oncogenesis. The …
[HTML][HTML] A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis
Ischemic stroke is the second leading cause of death worldwide with limited medications
and neuroinflammation was recognized as a critical player in the progression of stroke, but …
and neuroinflammation was recognized as a critical player in the progression of stroke, but …
[HTML][HTML] EZH2-mediated epigenetic silencing of miR-29/miR-30 targets LOXL4 and contributes to tumorigenesis, metastasis, and immune microenvironment …
H Yin, Y Wang, Y Wu, X Zhang, X Zhang, J Liu… - Theranostics, 2020 - ncbi.nlm.nih.gov
Abstract Enhancer of Zeste Homolog 2 (EZH2), a key epigenetic regulator, is involved in
breast cancer progression and metastasis. LOXL4 is increasingly recognized as an …
breast cancer progression and metastasis. LOXL4 is increasingly recognized as an …
[HTML][HTML] Long non-coding RNA HOTAIR is a powerful predictor of metastasis and poor prognosis and is associated with epithelial-mesenchymal transition in colon …
ZH Wu, XL Wang, HM Tang, T Jiang… - Oncology …, 2014 - spandidos-publications.com
Colon cancer is one of the most frequently diagnosed cancer and the third most fatal
malignancy worldwide. HOTAIR, a cancer-associated long non-coding RNA (lncRNA), is a …
malignancy worldwide. HOTAIR, a cancer-associated long non-coding RNA (lncRNA), is a …