Epithelial cells are the most common cell type in all animals, forming the sheets and tubes
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …

Approximately one percent of the human genome encodes proteins that either regulate or
are regulated by direct interaction with members of the Rho family of small GTPases …

The sequencing of complete genomes provides a list that includes the proteins responsible
for cellular regulation. However, this does not immediately reveal what these proteins do …

Spermatogenesis is the cellular process by which spermatogonia develop into mature
spermatids within seminiferous tubules, the functional unit of the mammalian testis, under …

Stem cells self-renew but also give rise to daughter cells that are committed to lineage-
specific differentiation. To achieve this remarkable task, they can undergo an intrinsically …

During organogenesis, epithelial cells can give rise to mesenchymal cells through epithelial–
mesenchymal transition. The reverse process, mesenchymal–epithelial transition (MET), can …

The transition of cells from an epithelial to a mesenchymal phenotype is a critical event
during morphogenesis in multicellular organisms and underlies the pathology of many …

All cell types polarize, at least transiently, during division or to generate specialized shapes
and functions. This capacity extends from yeast to mammals, and it is now clear that many …

Tight junctions (TJs) regulate the passage of ions and molecules through the paracellular
pathway in epithelial and endothelial cells. TJs are highly dynamic structures whose degree …

How do animal cells assemble into tissues and organs? A diverse array of tissue structures
and shapes can be formed by organizing groups of cells into different polarized …