[HTML][HTML] The world of protein acetylation
Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
Co-translational, post-translational, and non-catalytic roles of N-terminal acetyltransferases
Recent studies of N-terminal acetylation have identified new N-terminal acetyltransferases
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …
First things first: vital protein marks by N-terminal acetyltransferases
N-terminal (Nt) acetylation is known to be a highly abundant co-translational protein
modification, but the recent discovery of Golgi-and chloroplast-resident N-terminal …
modification, but the recent discovery of Golgi-and chloroplast-resident N-terminal …
Post-translational modifications of the protein termini
Post-translational modifications (PTM) involve enzyme-mediated covalent addition of
functional groups to proteins during or after synthesis. These modifications greatly increase …
functional groups to proteins during or after synthesis. These modifications greatly increase …
Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans
T Arnesen, P Van Damme… - Proceedings of the …, 2009 - National Acad Sciences
Nα-terminal acetylation is one of the most common protein modifications in eukaryotes. The
COmbined FRActional DIagonal Chromatography (COFRADIC) proteomics technology that …
COmbined FRActional DIagonal Chromatography (COFRADIC) proteomics technology that …
Protein N-terminal acetyltransferases: when the start matters
The majority of eukaryotic proteins are subjected to N-terminal acetylation (Nt-acetylation),
catalysed by N-terminal acetyltransferases (NATs). Recently, the structure of an NAT …
catalysed by N-terminal acetyltransferases (NATs). Recently, the structure of an NAT …
N‐terminal modifications of cellular proteins: the enzymes involved, their substrate specificities and biological effects
The vast majority of eukaryotic proteins are N‐terminally modified by one or more
processing enzymes. Enzymes acting on the very first amino acid of a polypeptide include …
processing enzymes. Enzymes acting on the very first amino acid of a polypeptide include …
N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins
B Polevoda, F Sherman - Journal of molecular biology, 2003 - Elsevier
Nα-terminal acetylation occurs in the yeast Saccharomyces cerevisiae by any of three N-
terminal acetyltransferases (NAT), NatA, NatB, and NatC, which contain Ard1p, Nat3p and …
terminal acetyltransferases (NAT), NatA, NatB, and NatC, which contain Ard1p, Nat3p and …
Protein N-terminal methionine excision
N-terminal methionine excision (NME) is the major proteolytic pathway responsible for the
diversity of N-terminal amino acids in proteins. Dedicated NME components have been …
diversity of N-terminal amino acids in proteins. Dedicated NME components have been …
Towards a functional understanding of protein N-terminal acetylation
T Arnesen - PLoS biology, 2011 - journals.plos.org
Protein N-terminal acetylation is a major modification of eukaryotic proteins. Its functional
implications include regulation of protein–protein interactions and targeting to membranes …
implications include regulation of protein–protein interactions and targeting to membranes …