[HTML][HTML] The world of protein acetylation

A Drazic, LM Myklebust, R Ree, T Arnesen - Biochimica et Biophysica Acta …, 2016 - Elsevier
Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

Co-translational, post-translational, and non-catalytic roles of N-terminal acetyltransferases

H Aksnes, R Ree, T Arnesen - Molecular cell, 2019 - cell.com
Recent studies of N-terminal acetylation have identified new N-terminal acetyltransferases
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …

First things first: vital protein marks by N-terminal acetyltransferases

H Aksnes, A Drazic, M Marie, T Arnesen - Trends in biochemical sciences, 2016 - cell.com
N-terminal (Nt) acetylation is known to be a highly abundant co-translational protein
modification, but the recent discovery of Golgi-and chloroplast-resident N-terminal …

Post-translational modifications of the protein termini

L Chen, A Kashina - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Post-translational modifications (PTM) involve enzyme-mediated covalent addition of
functional groups to proteins during or after synthesis. These modifications greatly increase …

Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans

T Arnesen, P Van Damme… - Proceedings of the …, 2009 - National Acad Sciences
Nα-terminal acetylation is one of the most common protein modifications in eukaryotes. The
COmbined FRActional DIagonal Chromatography (COFRADIC) proteomics technology that …

Protein N-terminal acetyltransferases: when the start matters

KK Starheim, K Gevaert, T Arnesen - Trends in biochemical sciences, 2012 - cell.com
The majority of eukaryotic proteins are subjected to N-terminal acetylation (Nt-acetylation),
catalysed by N-terminal acetyltransferases (NATs). Recently, the structure of an NAT …

N‐terminal modifications of cellular proteins: the enzymes involved, their substrate specificities and biological effects

S Varland, C Osberg, T Arnesen - Proteomics, 2015 - Wiley Online Library
The vast majority of eukaryotic proteins are N‐terminally modified by one or more
processing enzymes. Enzymes acting on the very first amino acid of a polypeptide include …

N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins

B Polevoda, F Sherman - Journal of molecular biology, 2003 - Elsevier
Nα-terminal acetylation occurs in the yeast Saccharomyces cerevisiae by any of three N-
terminal acetyltransferases (NAT), NatA, NatB, and NatC, which contain Ard1p, Nat3p and …

Protein N-terminal methionine excision

C Giglione, A Boularot, T Meinnel - Cellular and Molecular Life Sciences …, 2004 - Springer
N-terminal methionine excision (NME) is the major proteolytic pathway responsible for the
diversity of N-terminal amino acids in proteins. Dedicated NME components have been …

Towards a functional understanding of protein N-terminal acetylation

T Arnesen - PLoS biology, 2011 - journals.plos.org
Protein N-terminal acetylation is a major modification of eukaryotic proteins. Its functional
implications include regulation of protein–protein interactions and targeting to membranes …