Gut microbiome, big data and machine learning to promote precision medicine for cancer

G Cammarota, G Ianiro, A Ahern, C Carbone… - Nature reviews …, 2020 - nature.com
The gut microbiome has been implicated in cancer in several ways, as specific microbial
signatures are known to promote cancer development and influence safety, tolerability and …

Precision medicine in the era of artificial intelligence: implications in chronic disease management

M Subramanian, A Wojtusciszyn, L Favre… - Journal of translational …, 2020 - Springer
Aberrant metabolism is the root cause of several serious health issues, creating a huge
burden to health and leading to diminished life expectancy. A dysregulated metabolism …

A longitudinal big data approach for precision health

SM Schüssler-Fiorenza Rose, K Contrepois… - Nature medicine, 2019 - nature.com
Precision health relies on the ability to assess disease risk at an individual level, detect early
preclinical conditions and initiate preventive strategies. Recent technological advances in …

[HTML][HTML] Profound perturbation of the metabolome in obesity is associated with health risk

ET Cirulli, L Guo, CL Swisher, N Shah, L Huang… - Cell metabolism, 2019 - cell.com
Obesity is a heterogeneous phenotype that is crudely measured by body mass index (BMI).
There is a need for a more precise yet portable method of phenoty** and categorizing risk …

Practicing precision medicine with intelligently integrative clinical and multi-omics data analysis

Z Ahmed - Human genomics, 2020 - Springer
Precision medicine aims to empower clinicians to predict the most appropriate course of
action for patients with complex diseases like cancer, diabetes, cardiomyopathy, and COVID …

Cooperative learning for multiview analysis

DY Ding, S Li, B Narasimhan… - Proceedings of the …, 2022 - National Acad Sciences
We propose a method for supervised learning with multiple sets of features (“views”). The
multiview problem is especially important in biology and medicine, where “-omics” data …

The future of precision medicine in the cure of Alzheimer's disease

A Arafah, S Khatoon, I Rasool, A Khan, MA Rather… - Biomedicines, 2023 - mdpi.com
This decade has seen the beginning of ground-breaking conceptual shifts in the research of
Alzheimer's disease (AD), which acknowledges risk elements and the evolving wide …

Precision medicine integrating whole-genome sequencing, comprehensive metabolomics, and advanced imaging

YCC Hou, HC Yu, R Martin, ET Cirulli… - Proceedings of the …, 2020 - National Acad Sciences
Genome sequencing has established clinical utility for rare disease diagnosis. While
increasing numbers of individuals have undergone elective genome sequencing, a …

Metabolomics in the clinic: A review of the shared and unique features of untargeted metabolomics for clinical research and clinical testing

AD Kennedy, BM Wittmann, AM Evans… - Journal of Mass …, 2018 - Wiley Online Library
Metabolomics is the untargeted measurement of the metabolome, which is composed of the
complement of small molecules detected in a biological sample. As such, metabolomic …

Precision medicine and the problem of structural injustice

S Green, B Prainsack, M Sabatello - Medicine, Health Care and …, 2023 - Springer
Many countries currently invest in technologies and data infrastructures to foster precision
medicine (PM), which is hoped to better tailor disease treatment and prevention to individual …