Deep learning-enabled virtual histological staining of biological samples

B Bai, X Yang, Y Li, Y Zhang, N Pillar… - Light: Science & …, 2023 - nature.com
Histological staining is the gold standard for tissue examination in clinical pathology and life-
science research, which visualizes the tissue and cellular structures using chromatic dyes or …

Artificial intelligence to identify genetic alterations in conventional histopathology

D Cifci, S Foersch, JN Kather - The Journal of pathology, 2022 - Wiley Online Library
Precision oncology relies on the identification of targetable molecular alterations in tumor
tissues. In many tumor types, a limited set of molecular tests is currently part of standard …

Deep learning-based virtual staining, segmentation, and classification in label-free photoacoustic histology of human specimens

C Yoon, E Park, S Misra, JY Kim, JW Baik… - Light: Science & …, 2024 - nature.com
In pathological diagnostics, histological images highlight the oncological features of excised
specimens, but they require laborious and costly staining procedures. Despite recent …

Noninvasive virtual biopsy using micro-registered optical coherence tomography (OCT) in human subjects

Y Winetraub, A Van Vleck, E Yuan, I Terem, J Zhao… - Science …, 2024 - science.org
Histological hematoxylin and eosin–stained (H&E) tissue sections are used as the gold
standard for pathologic detection of cancer, tumor margin detection, and disease diagnosis …

Virtual staining for histology by deep learning

L Latonen, S Koivukoski, U Khan, P Ruusuvuori - Trends in Biotechnology, 2024 - cell.com
In pathology and biomedical research, histology is the cornerstone method for tissue
analysis. Currently, the histological workflow consumes plenty of chemicals, water, and time …

An ultraviolet‐transparent ultrasound transducer enables high‐resolution label‐free photoacoustic histopathology

D Kim, E Park, J Park, B Perleberg… - Laser & Photonics …, 2024 - Wiley Online Library
Ultraviolet photoacoustic microscopy (UV‐PAM), based on the high intrinsic optical
absorption of DNA/RNA, holds great promise for intraoperative label‐free histopathological …

Virtual histological staining of unlabeled autopsy tissue

Y Li, N Pillar, J Li, T Liu, D Wu, S Sun, G Ma… - Nature …, 2024 - nature.com
Traditional histochemical staining of post-mortem samples often confronts inferior staining
quality due to autolysis caused by delayed fixation of cadaver tissue, and such chemical …

Recent advances in deep-learning-enhanced photoacoustic imaging

J Yang, S Choi, J Kim, B Park… - Advanced Photonics …, 2023 - spiedigitallibrary.org
Photoacoustic imaging (PAI), recognized as a promising biomedical imaging modality for
preclinical and clinical studies, uniquely combines the advantages of optical and ultrasound …

Deep learning-enabled realistic virtual histology with ultraviolet photoacoustic remote sensing microscopy

MT Martell, NJM Haven, BD Cikaluk, BS Restall… - Nature …, 2023 - nature.com
The goal of oncologic surgeries is complete tumor resection, yet positive margins are
frequently found postoperatively using gold standard H&E-stained histology methods …

Virtual histological staining of label-free total absorption photoacoustic remote sensing (TA-PARS)

M Boktor, BR Ecclestone, V Pekar, D Dinakaran… - Scientific Reports, 2022 - nature.com
Histopathological visualizations are a pillar of modern medicine and biological research.
Surgical oncology relies exclusively on post-operative histology to determine definitive …