The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

Transfer RNA (tRNA) is present at tens of millions of transcripts in a human cell and is the
most abundant RNA in moles among all cellular RNAs. tRNA is also the most extensively …

Cellular RNAs carry diverse chemical modifications that used to be regarded as static and
having minor roles in'fine-tuning'structural and functional properties of RNAs. In this Review …

Summary N 6-methyladenosine (m 6 A) is the most prevalent internal modification of
messenger RNA (mRNA) in higher eukaryotes. Here we report ALKBH5 as another …

The chemical identity of RNA molecules beyond the four standard ribonucleosides has
fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in …

2-Oxoglutarate (2OG)-dependent oxygenases (2OGXs) catalyze a remarkably diverse range
of oxidative reactions. In animals, these comprise hydroxylations and N-demethylations …

We report here that fat mass and obesity-associated protein (FTO) has efficient oxidative
demethylation activity targeting the abundant N 6-methyladenosine (m6A) residues in RNA …

The past several years have seen dramatic leaps in our understanding of how gene
expression is rewired at the translation level during tumorigenesis to support the …

The AlkB family of Fe (II)-and α-ketoglutarate-dependent dioxygenases is a class of
ubiquitous direct reversal DNA repair enzymes that remove alkyl adducts from nucleobases …

Posttranscriptional modifications of transfer RNAs (tRNAs) are critical for all core aspects of
tRNA function, such as folding, stability, and decoding. Most tRNA modifications were …