Viral vectors for gene transfer: a review of their use in the treatment of human diseases
W Walther, U Stein - Drugs, 2000 - Springer
The efficient delivery of therapeutic genes and appropriate gene expression are the crucial
issues for clinically relevant gene therapy. Viruses are naturally evolved vehicles which …
issues for clinically relevant gene therapy. Viruses are naturally evolved vehicles which …
Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans.
GJ Nabel, EG Nabel, ZY Yang, BA Fox… - Proceedings of the …, 1993 - National Acad Sciences
Direct gene transfer offers the potential to introduce DNA encoding therapeutic proteins to
treat human disease. Previously, gene transfer in humans has been achieved by a cell …
treat human disease. Previously, gene transfer in humans has been achieved by a cell …
Gene therapy for cancer
KW Culver, RM Blaese - Trends in Genetics, 1994 - Elsevier
Initiation of clinical trials of gene therapies for cancer has been made possible by two major
technological advances: the ability to clone genes that constitute the genetic basis of …
technological advances: the ability to clone genes that constitute the genetic basis of …
Strategic developments & future perspective on gene therapy for breast cancer: role of mTOR and Brk/PTK6 as molecular targets
Breast cancer is a serious health issue and a major concern in biomedical research.
Alteration in major signaling (viz. PI3K-AKT-mTOR, Ras-Raf-MEK-Erk, NF-kB, cyclin D1, JAK …
Alteration in major signaling (viz. PI3K-AKT-mTOR, Ras-Raf-MEK-Erk, NF-kB, cyclin D1, JAK …
Methods for promoting wound healing and treating transplant-associated vasculopathy
The present invention provides a method of promoting the closure of a Wound in a patient.
This method involves transferring exogenous iNOS to the region of the Wound Whereby a …
This method involves transferring exogenous iNOS to the region of the Wound Whereby a …
Methods for promoting wound healing and treating transplant-associated vasculopathy
Division of application No. 08/745,375, Nov. 8, 1996, Pat. No. 5,830,461, which is a
continuation-in-part of application No. 08/630,798, Apr. 10, 1996, abandoned, which is a …
continuation-in-part of application No. 08/630,798, Apr. 10, 1996, abandoned, which is a …
Plasmids suitable for gene therapy
GJ Nabel, EG Nabel, D Lew, M Marquet - US Patent 5,910,488, 1999 - Google Patents
US5910488A - Plasmids suitable for gene therapy - Google Patents US5910488A - Plasmids
suitable for gene therapy - Google Patents Plasmids suitable for gene therapy Download PDF …
suitable for gene therapy - Google Patents Plasmids suitable for gene therapy Download PDF …
Use of suicide genes in gene therapy
P Tiberghien - Journal of leukocyte biology, 1994 - Wiley Online Library
Gene therapy encompasses a broad range of treatment modalities that may eventually be
applied to a variety of genetic as well as acquired diseases. In addition to compensating for …
applied to a variety of genetic as well as acquired diseases. In addition to compensating for …
Gene therapy: a brief overview of the past, present, and future
R Scollay - Annals of the New York Academy of Sciences, 2001 - Wiley Online Library
Gene therapy has only recently begun to make serious progress, beginning with two
approved gene therapy trials in the United States in late 1990. The death of an 18‐year‐old …
approved gene therapy trials in the United States in late 1990. The death of an 18‐year‐old …
Reversal of multidrug resistance by transduction of cytokine genes into human colon carcinoma cells
U Stein, W Walther… - JNCI: Journal of the …, 1996 - academic.oup.com
Background: Multidrug resistance can be a major obstacle to successful cancer
chemotherapy and is often associated with increased expression of the mdr1 (also known as …
chemotherapy and is often associated with increased expression of the mdr1 (also known as …