Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …

Recently, a subset of neurons was identified in the arcuate nucleus of the hypothalamus that
colocalize three neuropeptides, kisspeptin, neurokinin B, and dynorphin, each of which has …

BACKGROUND The discovery of kisspeptin as key central regulator of GnRH secretion has
led to a new level of understanding of the neuroendocrine regulation of human reproduction …

Reproduction is controlled by the hypothalamic-pituitary-gonadal (HPG) axis. Gonadotropin-
releasing hormone (GnRH) neurons play a central role in this axis through production of …

Hypothalamic kisspeptin neurons serve as the nodal regulatory centre of reproductive
function. These neurons are subjected to a plethora of regulatory factors that ultimately affect …

Background: Bisphenol A (BPA) is one of the highest volume chemicals produced
worldwide. It has recognized activity as an endocrine-disrupting chemical and has …

Kisspeptin is a potent stimulator of GnRH secretion that has been implicated in the feedback
actions of ovarian steroids. In ewes, the majority of hypothalamic kisspeptin neurons are …

Context: Mutation of the G protein-coupled receptor 54 is associated with a failure of
reproductive function. The endogenous neuropeptide agonist for G protein-coupled receptor …

Leptin is an adipocyte‐derived hormone that acts on the hypothalamus to influence feeding,
metabolism and reproduction, but the cellular and molecular targets for the action of leptin in …