Respiratory epithelial cell responses to SARS-CoV-2 in COVID-19

JP Bridges, EK Vladar, H Huang, RJ Mason - Thorax, 2022 - thorax.bmj.com
COVID-19 has different clinical stages, and effective therapy depends on the location and
extent of the infection. The purpose of this review is to provide a background for …

SP-A and SP-D: dual functioning immune molecules with antiviral and immunomodulatory properties

A Watson, J Madsen, HW Clark - Frontiers in Immunology, 2021 - frontiersin.org
Surfactant proteins A (SP-A) and D (SP-D) are soluble innate immune molecules which
maintain lung homeostasis through their dual roles as anti-infectious and …

Alveolar type II cells and pulmonary surfactant in COVID-19 era

A Calkovska, M Kolomaznik… - Physiological …, 2021 - pmc.ncbi.nlm.nih.gov
In this review, we discuss the role of pulmonary surfactant in the host defense against
respiratory pathogens, including novel coronavirus SARS-CoV-2. In the lower respiratory …

The role of pulmonary surfactants in the treatment of acute respiratory distress syndrome in COVID-19

S Wang, Z Li, X Wang, S Zhang, P Gao… - Frontiers in …, 2021 - frontiersin.org
Lung alveolar type-II (AT-II) cells produce pulmonary surfactant (PS), consisting of proteins
and lipids. The lipids in PS are primarily responsible for reducing the air-fluid surface tension …

Role of respiratory epithelial cells in allergic diseases

CA Jakwerth, J Ordovas-Montanes, S Blank… - Cells, 2022 - mdpi.com
The airway epithelium provides the first line of defense to the surrounding environment.
However, dysfunctions of this physical barrier are frequently observed in allergic diseases …

Experimental techniques to study protein–surfactant interactions: New insights into competitive adsorptions via drop subphase and interface exchange

A Javadi, S Dowlati, S Shourni, R Miller… - Advances in Colloid and …, 2022 - Elsevier
Protein surfactant (Psingle bond S) interactions is an essential topic for many fundamental
and technological applications such as life science, nanobiotechnology processes, food …

Host cell entry mediators implicated in the cellular tropism of SARS-CoV-2, the pathophysiology of COVID-19 and the identification of microRNAs that can modulate …

P Katopodis, HS Randeva… - International …, 2022 - spandidos-publications.com
The pathophysiology of coronavirus disease 2019 (COVID-19) is mainly dependent on the
underlying mechanisms that mediate the entry of severe acute respiratory syndrome …

Human surfactant protein A inhibits SARS-CoV-2 infectivity and alleviates lung injury in a mouse infection model

IB Jacob, A Gemmiti, W **ong, E Reynolds… - Frontiers in …, 2024 - frontiersin.org
Introduction SARS coronavirus 2 (SARS-CoV-2) infects human angiotensin-converting
enzyme 2 (hACE2)-expressing lung epithelial cells through its spike (S) protein. The S …

Pulmonary surfactant as a versatile biomaterial to fight COVID-19

L Herman, SC De Smedt, K Raemdonck - Journal of Controlled Release, 2022 - Elsevier
The COVID-19 pandemic has wielded an enormous pressure on global health care systems,
economics and politics. Ongoing vaccination campaigns effectively attenuate viral …

Lung surfactant proteins as potential targets of prallethrin: an in silico approach

S Ghanty, M Mandi, A Ganguly, K Das, A Dutta… - Toxicology and …, 2022 - Springer
Object Prallethrin is a pyrethroid-based insecticide, commonly used as a liquid vaporizer in
household, schools, and offices to repel mosquitoes. Due to worldwide application, human …