Novel antimicrobial agents for combating antibiotic-resistant bacteria

RYK Chang, SC Nang, HK Chan, J Li - Advanced drug delivery reviews, 2022 - Elsevier
Antibiotic therapy has become increasingly ineffective against bacterial infections due to the
rise of resistance. In particular, ESKAPE pathogens (Enterococcus faecium, Staphylococcus …

Phage therapy in the postantibiotic era

FL Gordillo Altamirano, JJ Barr - Clinical microbiology reviews, 2019 - journals.asm.org
Antibiotic resistance is arguably the biggest current threat to global health. An increasing
number of infections are becoming harder or almost impossible to treat, carrying high …

Therapeutic potential of bacteriophage endolysins for infections caused by Gram-positive bacteria

H Liu, Z Hu, M Li, Y Yang, S Lu, X Rao - Journal of biomedical science, 2023 - Springer
Abstract Gram-positive (G+) bacterial infection is a great burden to both healthcare and
community medical resources. As a result of the increasing prevalence of multidrug-resistant …

Resistance development to bacteriophages occurring during bacteriophage therapy

F Oechslin - Viruses, 2018 - mdpi.com
Bacteriophage (phage) therapy, ie, the use of viruses that infect bacteria as antimicrobial
agents, is a promising alternative to conventional antibiotics. Indeed, resistance to antibiotics …

Antimicrobial peptides: new hope in the war against multidrug resistance

J Mwangi, X Hao, R Lai, ZY Zhang - Zoological research, 2019 - pmc.ncbi.nlm.nih.gov
The discovery of antibiotics marked a golden age in the revolution of human medicine.
However, decades later, bacterial infections remain a global healthcare threat, and a return …

[HTML][HTML] Phage-encoded endolysins

F Abdelrahman, M Easwaran, OI Daramola, S Ragab… - Antibiotics, 2021 - mdpi.com
Due to the global emergence of antibiotic resistance, there has been an increase in
research surrounding endolysins as an alternative therapeutic. Endolysins are phage …

Antimicrobial peptides

AA Bahar, D Ren - Pharmaceuticals, 2013 - mdpi.com
The rapid increase in drug-resistant infections has presented a serious challenge to
antimicrobial therapies. The failure of the most potent antibiotics to kill “superbugs” …

Antibiotic alternatives: the substitution of antibiotics in animal husbandry?

G Cheng, H Hao, S **e, X Wang, M Dai… - Frontiers in …, 2014 - frontiersin.org
It is a common practice for decades to use of sub-therapeutic dose of antibiotics in food-
animal feeds to prevent animals from diseases and to improve production performance in …

[HTML][HTML] Treating bacterial infections with bacteriophage-based enzybiotics: in vitro, in vivo and clinical application

KM Danis-Wlodarczyk, DJ Wozniak, ST Abedon - Antibiotics, 2021 - mdpi.com
Over the past few decades, we have witnessed a surge around the world in the emergence
of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and …

The antimicrobial peptide ZY4 combats multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii infection

J Mwangi, Y Yin, G Wang, M Yang, Y Li… - Proceedings of the …, 2019 - pnas.org
The emergence of carbapenem-resistant Acinetobacter baumannii and Pseudomonas
aeruginosa raises fears of untreatable infections and poses the greatest health threats …