Platelet hyperreactivity and hyperlipidaemia contribute significantly to atherosclerosis. Thus,
it is desirable to review the platelet–hyperlipidaemia interplay and its impact on …

Identifying therapeutics to delay, and potentially reverse, age-related cognitive decline is
critical in light of the increased incidence of dementia-related disorders forecasted in the …

The main cause of death in melanoma patients is widespread metastases. Staging of
melanoma is based on the primary tumor thickness, ulceration, lymph node and distant …

The beneficial effects of physical activity on brain ageing are well recognised, with
exerkines, factors that are secreted into the circulation in response to exercise, emerging as …

Platelet factors regulate wound healing and can signal from the blood to the brain,.
However, whether platelet factors modulate cognition, a highly valued and central …

In the bone marrow, hematopoietic stem cells (HSCs) lodge in specialized
microenvironments that tightly control the proliferative state of HSCs to adapt to the varying …

Heparin-induced thrombocytopenia (HIT) is an immune-mediated thrombocytopenic
disorder associated with a severe prothrombotic state. We investigated whether neutrophils …

Fibrosis is a major cause of mortality worldwide, characterized by myofibroblast activation
and excessive extracellular matrix deposition. Systemic sclerosis is a prototypic fibrotic …

Coagulation has long been known to facilitate metastasis. To pinpoint the steps where
coagulation might play a role in the metastasis, we used three-dimensional visualization of …

Blood clotting is a finely regulated process that is essential for hemostasis. However, when
dysregulated or spontaneous, it promotes thrombotic disorders. The fact that these are …