Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

A genetic basis of congenital isolated hypogonadotropic hypogonadism (CHH) can be
defined in almost 50% of cases, albeit not necessarily the complete genetic basis. Next …

Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …

BACKGROUND Human reproduction depends on an intact hypothalamic–pituitary–gonadal
(HPG) axis. Hypothalamic gonadotrophin-releasing hormone (GnRH) has been recognized …

We examined the role of kisspeptin and its receptor, the G-protein-coupled receptor GPR54,
in governing the onset of puberty in the mouse. In the adult male and female mouse …

Background A single family has been described in which obesity results from a mutation in
the leptin-receptor gene (LEPR), but the prevalence of such mutations in severe, early-onset …

Gonadotropin-dependent, or central, precocious puberty is caused by early maturation of the
hypothalamic–pituitary–gonadal axis. In girls, this condition is most often idiopathic …

Context: Mutation of the G protein-coupled receptor 54 is associated with a failure of
reproductive function. The endogenous neuropeptide agonist for G protein-coupled receptor …

Studies have implicated oxidative stress-sensitive signaling in the pathogenesis of stress-
induced male infertility. However, apart from oxidative stress, gonadotropin inhibitory …

The G protein-coupled receptor GPR54 (AXOR12, OT7T175) is central to acquisition of
reproductive competency in mammals. Peptide ligands (kisspeptins) for this receptor are …