Metabotropic γ-aminobutyric acid G protein–coupled receptors (GABAB) represent one of
the two main types of inhibitory neurotransmitter receptors in the brain. These receptors act …

Single particle cryo-electron microscopy (cryo-EM) has matured into a robust method for the
determination of biological macromolecule structures in the past decade, complementing X …

Parkinson's disease (PD) is the most common movement disorder, with resting tremor,
rigidity, bradykinesia and postural instability being major symptoms. Neuropathologically, it …

The ordered assembly of tau protein into filaments characterizes several neurodegenerative
diseases, which are called tauopathies. It was previously reported that, by cryo-electron …

The coronavirus membrane protein (M) is the most abundant viral structural protein and
plays a central role in virus assembly and morphogenesis. However, the process of M …

Cryo-electron microscopy (cryo-EM) single-particle analysis has proven powerful in
determining the structures of rigid macromolecules. However, many imaged protein …

Single-particle electron cryo-microscopy (cryo-EM) is a powerful method for solving the three-
dimensional structures of biological macromolecules. The technological development of …

The abnormal aggregation of TAR DNA-binding protein 43 kDa (TDP-43) in neurons and
glia is the defining pathological hallmark of the neurodegenerative disease amyotrophic …

Abundant filamentous inclusions of tau are characteristic of more than 20
neurodegenerative diseases that are collectively termed tauopathies. Electron cryo …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the current coronavirus disease 2019 (COVID-19) pandemic. A major virulence factor of …