Ari Helenius launched the field of enveloped virus fusion in endosomes with a seminal
paper in the Journal of Cell Biology in 1980. In the intervening years, a great deal has been …

There are at least 21 families of enveloped viruses that infect mammals, and many contain
members of high concern for global human health. All enveloped viruses have a dedicated …

SARS-CoV-2 is associated with broad tissue tropism, a characteristic often determined by
the availability of entry receptors on host cells. Here, we show that TMEM106B, a lysosomal …

Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 as a highly
transmissible pathogenic human betacoronavirus. The viral spike glycoprotein (S) utilizes …

Here we describe the complete genome of a new ebolavirus, Bombali virus (BOMV)
detected in free-tailed bats in Sierra Leone (little free-tailed (Chaerephon pumilus) and …

Antibodies serve as critical barriers to viral infection. Humoral immunity to a virus is achieved
through the dual role of antibodies in communicating the presence of invading pathogens in …

Niemann-Pick disease type C (NPC) is associated with mutations in NPC1 and NPC2,
whose gene products are key players in the endosomal/lysosomal egress of low-density …

Monoclonal antibodies can provide important pre-or post-exposure protection against
infectious disease for those not yet vaccinated or in individuals that fail to mount a protective …

Hedgehog protein signals mediate tissue patterning and maintenance by binding to and
inactivating their common receptor Patched, a 12-transmembrane protein that otherwise …

Lysosomes degrade and recycle macromolecules that are delivered through the
biosynthetic, endocytic, and autophagic routes. Hydrolysis of the different classes of …