During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …

The development and progression of human cancers are continuously and dynamically
regulated by intrinsic and extrinsic factors. As a converging point of multiple oncogenic …

Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic
transcription factors that mediate intracellular signaling that is usually generated at cell …

Glioblastoma multiforme (GBM), an aggressive tumor that typically exhibits treatment failure
with high mortality rates, is associated with the presence of cancer stem cells (CSCs) within …

Previously undescribed prognostic subclasses of high-grade astrocytoma are identified and
discovered to resemble stages in neurogenesis. One tumor class displaying neuronal …

Glioblastoma (GBM) is the most malignant brain tumor and accounts for most adult brain
tumors. Current available treatment options for GBM are multimodal, which include surgical …

Human solid tumors frequently have pronounced heterogeneity of both neoplastic and
normal cells on the histological, genetic, and gene expression levels. While current efforts …

Signal transducer and activator of transcription (STAT) 3 is a key signalling protein engaged
by a multitude of growth factors and cytokines to elicit diverse biological outcomes including …

JAK-STAT is an efficient and highly regulated system mainly dedicated to the regulation of
gene expression. Primarily identified as functioning in hematopoietic cells, its role has been …

Microglia, which contribute substantially to the tumor mass of glioblastoma, have been
shown to play an important role in glioma growth and invasion. While a large number of …