Recent developments in bioprocessing of recombinant proteins: expression hosts and process development

NK Tripathi, A Shrivastava - Frontiers in Bioengineering and …, 2019 - frontiersin.org
Infectious diseases, along with cancers, are among the main causes of death among
humans worldwide. The production of therapeutic proteins for treating diseases at large …

Challenges and progress towards industrial recombinant protein production in yeasts: a review

P De Brabander, E Uitterhaegen, T Delmulle… - Biotechnology …, 2023 - Elsevier
Recombinant proteins (RP) are widely used as biopharmaceuticals, industrial enzymes, or
sustainable food source. Yeasts, with their ability to produce complex proteins through a …

How far have we explored fungi to fight cancer?

CW How, YS Ong, SS Low, A Pandey, PL Show… - Seminars in cancer …, 2022 - Elsevier
The use of fungal cultures have been well documented in human history. Although its used
in healthcare, like penicillin and statins, have saved countless of lives, but there is still no …

A review of yeast: High cell-density culture, molecular mechanisms of stress response and tolerance during fermentation

D Shen, X He, P Weng, Y Liu, Z Wu - FEMS Yeast Research, 2022 - academic.oup.com
Yeast is widely used in the fermentation industry, and the major challenges in fermentation
production system are high capital cost and low reaction rate. High cell-density culture is an …

Continuous Cultivation as a Tool Toward the Rational Bioprocess Development With Pichia Pastoris Cell Factory

MA Nieto-Taype, X Garcia-Ortega, J Albiol… - … in bioengineering and …, 2020 - frontiersin.org
The methylotrophic yeast Pichia pastoris (Komagataella phaffii) is currently considered one
of the most promising hosts for recombinant protein production (RPP) and metabolites due …

[HTML][HTML] Methanol-based biomanufacturing of fuels and chemicals using native and synthetic methylotrophs

A Sarwar, EY Lee - Synthetic and Systems Biotechnology, 2023 - Elsevier
Methanol has recently gained significant attention as a potential carbon substrate for the
production of fuels and chemicals, owing to its high degree of reduction, abundance, and …

Enhancing the recombinant protein productivity of Yarrowia lipolytica using in situ fibrous bed bioreactor

JH Mou, IB Tahar, ZY Wang, KL Ong, C Li, ZH Qin… - Bioresource …, 2021 - Elsevier
In this study, the ability of Yarrowia lipolytica to produce the recombinant lipase CalB from
Candida antarctica, used as a model protein has been compared across different bioreactor …

A novel application of ion exchange chromatography in recombinant hepatitis B vaccine downstream processing: Improving recombinant HBsAg homogeneity by …

Z Kimia, SN Hosseini, SSA Talesh, M Khatami… - … of Chromatography B, 2019 - Elsevier
Production of recombinant HBsAg as a main component of the hepatitis B vaccine has
already been established in commercial scale. So far, many studies have been performed to …

High-density cultivation in the production of microbial products

R Subramaniam, V Thirumal, A Chistoserdov… - Chemical and …, 2018 - hrcak.srce.hr
Sažetak Microbial fermentation processes are of great importance for the production of many
bioproducts. Even for established processes, improvements in product yield, productivity …

Magnetic Immobilization of Pichia pastoris Cells for the Production of Recombinant Human Serum Albumin

SM Taghizadeh, A Ebrahiminezhad, MB Ghoshoon… - Nanomaterials, 2020 - mdpi.com
Magnetic immobilization as a novel technique was used to immobilize recombinant Pichia
pastoris (GS115 Albumin) cells to produce human serum albumin (HSA). In this regard …