COX-2: a molecular target for colorectal cancer prevention
JR Brown, RN DuBois - Journal of Clinical Oncology, 2005 - ascopubs.org
Cyclooxygenase (COX), a key enzyme in the prostanoid biosynthetic pathway, has received
considerable attention due to its role in human cancers. Observational and randomized …
considerable attention due to its role in human cancers. Observational and randomized …
Cyclooxygenase-2: how good is it as a target for cancer chemoprevention?
MA Hull - European Journal of Cancer, 2005 - Elsevier
There is now substantial evidence for a role for cyclooxygenase-2 (COX-2)-mediated
prostaglandin (PG) signalling during carcinogenesis in a number of tissues and selective …
prostaglandin (PG) signalling during carcinogenesis in a number of tissues and selective …
The effect of the selective cyclooxygenase-2 inhibitor rofecoxib on human colorectal cancer liver metastases
SW Fenwick, GJ Toogood, JPA Lodge, MA Hull - Gastroenterology, 2003 - Elsevier
Background & Aims: Cyclooxygenase-2 (COX-2) is a potential target for chemotherapy of
colorectal cancer (CRC). We tested the antineoplastic activity of the selective COX-2 …
colorectal cancer (CRC). We tested the antineoplastic activity of the selective COX-2 …
EP1–4 subtype, COX and PPARγ receptor expression in colorectal cancer in prediction of disease‐specific mortality
A Gustafsson, E Hansson, U Kressner… - … journal of cancer, 2007 - Wiley Online Library
The importance of prostaglandins in tumor growth and progression is well recognized,
including antineoplastic activities by cyclooxygenase (COX) inhibitors. Variation in treatment …
including antineoplastic activities by cyclooxygenase (COX) inhibitors. Variation in treatment …
Association between Cyclooxygenase Expression and Colorectal Adenoma Characteristics
JG Einspahr, RS Krouse, JM Yochim, PV Danenberg… - Cancer research, 2003 - AACR
The cyclooxygenase (COX) pathway is important in colorectal carcinogenesis with the
majority of cancers overexpressing COX-2; however, the role of COX-2 in the development …
majority of cancers overexpressing COX-2; however, the role of COX-2 in the development …
Celecoxib induces proliferation and Amphiregulin production in colon subepithelial myofibroblasts, activating erk1–2 signaling in synergy with EGFR
The COX-2 inhibitor Celecoxib, tested in phase III trials for the prevention of sporadic colon
adenomas, reduced the appearance of new adenomas, but was unable to affect the …
adenomas, reduced the appearance of new adenomas, but was unable to affect the …
Current status and future perspectives of chemoprevention in head and neck cancer
CM Klass, DM Shin - Current cancer drug targets, 2007 - ingentaconnect.com
The incidence of SCCHN is expected to be approximately 42,800 new cases in the United
States with more than 12,000 deaths from this disease for the year 2006. The five-year …
States with more than 12,000 deaths from this disease for the year 2006. The five-year …
Colon polyps and cancer
O Kronborg - Endoscopy, 2004 - thieme-connect.com
Screening for colorectal neoplasia still is the best method of reducing the mortality due to
colorectal cancer, and it is to be hoped that fecal occult blood test programs will expand in …
colorectal cancer, and it is to be hoped that fecal occult blood test programs will expand in …
Molecular mechanisms involved in the antiproliferative effect of two COX-2 inhibitors, nimesulide and NS-398, on colorectal cancer cell lines
B Buecher, A Broquet, D Bouancheau… - Digestive and liver …, 2003 - Elsevier
Background. Cyclooxygenase (COX)-2 is up-regulated in most colorectal cancers. Chronic
use of non-steroidal anti-inflammatory drugs, which target cyclooxygenases, have been …
use of non-steroidal anti-inflammatory drugs, which target cyclooxygenases, have been …
EGF receptor and COX-1/COX-2 enzyme proteins as related to corresponding mRNAs in human per-operative biopsies of colorectal cancer
AG Asting, A Farivar, BM Iresjö, H Svensson… - BMC cancer, 2013 - Springer
Background Cyclooxygenase (COX) and epidermal growth factor receptor (EGFR) activities
promote progression of colorectal cancer. Combined treatment against these targets has not …
promote progression of colorectal cancer. Combined treatment against these targets has not …