A continual rise in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection
causing coronavirus disease (COVID-19) has become a global threat. The main problem …

Single amino-acid substitution in a protein affects its structure and function. These changes
are the primary reasons for the advent of many complex diseases. Analyzing single point …

Metabolic reprogramming is a key attribute of cancer progression. An altered expression of
pyruvate kinase M2 (PKM2), a phosphotyrosine-binding protein is observed in many human …

Conserved telomere maintenance component 1 (CTC1) is an important component of the
CST (CTC1-STN1-TEN1) complex, involved in maintaining the stability of telomeric DNA …

Telomeric repeat binding factor 1 (TRF1) is one of the major components of the shelterin
complex. It directly binds to the telomere and controls its function by regulating the …

Abstract Phosphatidylinositol 4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA)
plays a crucial role in signaling pathways and has emerged as an attractive target for …

Abstract Tank‐binding kinase 1 (TBK1) is a serine/threonine protein kinase involved in
various signaling pathways and subsequently regulates cell proliferation, apoptosis …

Abstract Background Cytochrome P450 4F2 (CYP4F2) enzyme is a member of the CYP4
family responsible for the metabolism of fatty acids, therapeutic drugs, and signaling …

The activity of UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) is essential for the
biosynthesis of sialic acid, which is involved in cellular processes in health and diseases …

Hypogammaglobulinemia without B-cells is a subgroup of inborn errors of immunity (IEI)
which is characterized by a significant decline in all serum immunoglobulin isotypes …