Macrophages, circulating in the blood or concatenated into different organs and tissues
constitute the first barrier against any disease. They are foremost controllers of both innate …

Triggering receptor expressed on myeloid cells-1 (TREM-1) is expressed on the majority of
innate immune cells and to a lesser extent on parenchymal cells. Upon activation, TREM-1 …

MicroRNAs (miRNAs) are critical mediators of posttranscriptional regulation via their
targeting of the imperfect antisense complementary regions of coding and non-coding …

Inflammatory M1 spectrum macrophages protect from infection but can cause inflammatory
disease and tissue damage, whereas alternatively activated/M2 spectrum macrophages …

Hyperoxia-induced acute lung injury (HALI) is a key contributor to the pathogenesis of
bronchopulmonary dysplasia (BPD) in neonates, for which no specific preventive or …

Sepsis is a critical condition characterized by increased levels of pro-inflammatory cytokines
and proliferating cells such as neutrophils and macrophages in response to microbial …

Uncontrolled inflammatory responses play a critical role in coronavirus disease (COVID-19).
In this context, because the triggering-receptor expressed on myeloid cells-1 (TREM-1) is …

Pulmonary fibrosis (PF) is a disease in which excessive extracellular matrix (ECM)
accumulation occurs in pulmonary mesenchyme, which induces the destruction of alveolar …

Background A significant proportion of septic patients with acute lung injury (ALI) are
recognized late due to the absence of an efficient diagnostic test, leading to the postponed …

Micro-RNAs (miRs) are short, noncoding RNAs that negatively regulate gene expression at
the post-transcriptional level and have been implicated in the pathophysiology of secondary …