The dura, arachnoid and pia mater, as the constituent layers of the meninges, along with
cerebrospinal fluid in the subarachnoid space and ventricles, are essential protectors of the …

Lymphatic transport maintains homeostatic health and is necessary for immune surveillance,
and yet lymphatic growth is often associated with solid tumour development and …

Classical migraine patients experience aura, which is transient neurological deficits
associated with cortical spreading depression (CSD), preceding headache attacks. It is not …

Cervical lymphatic vessels (cLVs) have been shown to drain solutes and cerebrospinal fluid
(CSF) from the brain. However, their hydrodynamical properties have never been evaluated …

Mammalian brain border-associated macrophages (BAMs) are strategically positioned to
support vital properties and processes: for example, the composition of the brain's …

Impaired clearance of amyloid β (Aβ) in late-onset Alzheimer's disease (AD) affects disease
progression. The role of peripheral monocytes in Aβ clearance from the central nervous …

Multiphoton fluorescence microscopy (MPFM) has been a game-changer for optical
imaging, particularly for studying biological tissues deep within living organisms. MPFM …

Despite the presence of strategically positioned anatomical barriers designed to protect the
central nervous system (CNS), it is not entirely isolated from the immune system 1, 2. In fact …

The ecosystem of brain tumors is considered immunosuppressed, but our current
knowledge may be incomplete. Here we analyzed clinical cell and tissue specimens derived …

The glymphatic pathway was defined in rodents as a network of perivascular spaces (PVSs)
that facilitates organized distribution of cerebrospinal fluid (CSF) into the brain parenchyma …