The observation that heart failure with reduced ejection fraction is associated with elevated
circulating levels of pro-inflammatory cytokines opened a new area of research that has …

Conduction disorders and arrhythmias remain difficult to treat and are increasingly prevalent
owing to the increasing age and body mass of the general population, because both are risk …

Fig. 1| Autoimmune and inflammatory cardiac channelopathies and arrhythmias: molecular
basis. Autoantibodies and inflammatory cytokines can modulate the function of cardiac ion …

Each injection of any known vaccine results in a strong expression of pro-inflammatory
cytokines. This is the result of the innate immune system activation, without which no …

Autoimmune diseases are diseases that cause damage to the body's own tissues as a result
of immune dysfunction, often involving multiple organs and systems. The heart is one of the …

Increased proinflammatory interleukin-6 (IL-6) levels are associated with acquired long QT-
syndrome (LQTS) in patients with systemic inflammation, leading to higher risks for life …

Cardiac arrhythmias are associated with high morbidity and mortality. 1 Specifically,
malignant arrhythmias are a recognized leading cause of sudden cardiac death (SCD) in the …

Background Myocarditis is a highly morbid complication of immune checkpoint inhibitor (ICI)
use that remains inadequately characterized. The QRS duration and the QTc interval are …

Abstract Purpose of Review The intricate interplay between inflammatory and reparative
responses in the context of heart injury is central to the pathogenesis of heart failure. Recent …

Cardiac automaticity is set by pacemaker activity of the sinus node (SAN). In addition to the
ubiquitously expressed cardiac voltage-gated L-type Cav1. 2 Ca2+ channel isoform …