Objectives To compare the time to treatment failure, remission and first seizure of 12 AEDs
(carbamazepine, phenytoin, sodium valproate, phenobarbitone, oxcarbazepine, lamotrigine …

Background There is evidence that certain antiepileptic drugs (AEDs) are teratogenic and
are associated with an increased risk of congenital malformation. The majority of women …

Since the serendipitous discovery of its anticonvulsant properties more than 50 years ago,
valproic acid has become established as an effective broad-spectrum antiepileptic drug that …

Thirty-five years since its introduction into clinical use, valproate (valproic acid) has become
the most widely prescribed antiepileptic drug (AED) worldwide. Its pharmacological effects …

Valproic acid (VPA) is a known human teratogen. Exposure in pregnancy is associated with
approximately three-fold increase in the rate of major anomalies, mainly spina bifida and …

PURPOSE: To conduct a systematic review and meta-analysis to quantify the incidence of
congenital malformations (CMs) and other pregnancy outcomes as a function of in utero anti …

Most women with active epilepsy need treatment with antiepileptic drugs during pregnancy.
Antiepileptic drugs are also frequently used for other indications, such as migraine, pain …

Long‐term antiepileptic drug (AED) therapy is the reality for the majority of patients
diagnosed with epilepsy. One AED will usually be sufficient to control seizures effectively …

Objective: To reassess the evidence for management issues related to the care of women
with epilepsy (WWE) during pregnancy. Methods: Systematic review of relevant articles …

Objective: To compare the risk for congenital malformations in offspring between women
with epilepsy being treated with antiepileptic drugs (AEDs) during pregnancy and those who …