Macrolides: From toxins to therapeutics
Macrolides are a diverse class of hydrophobic compounds characterized by a macrocyclic
lactone ring and distinguished by variable side chains/groups. Some of the most well …
lactone ring and distinguished by variable side chains/groups. Some of the most well …
Buruli ulcer: a review of the current knowledge
Abstract Purpose of the Review Buruli ulcer (BU) is a necrotizing and disabling cutaneous
disease caused by Mycobacterium ulcerans, one of the skin-related neglected tropical …
disease caused by Mycobacterium ulcerans, one of the skin-related neglected tropical …
Phage therapy as a renewed therapeutic approach to mycobacterial infections: a comprehensive review
Mycobacterial infections are considered to a serious challenge of medicine, and the
emergence of MDR and XDR tuberculosis is a serious public health problem. Tuberculosis …
emergence of MDR and XDR tuberculosis is a serious public health problem. Tuberculosis …
[HTML][HTML] Non-tuberculous mycobacterial infections—a neglected and emerging problem
Non-tuberculous mycobacteria (NTM) are ubiquitous dwellers of environmental niches and
are an established cause of natural and nosocomial infections. The incidence of NTM …
are an established cause of natural and nosocomial infections. The incidence of NTM …
Sec61 blockade by mycolactone: A central mechanism in Buruli ulcer disease
Infection with Mycobacterium ulcerans results in a necrotising skin disease known as a
Buruli ulcer, the pathology of which is directly linked to the bacterial production of the toxin …
Buruli ulcer, the pathology of which is directly linked to the bacterial production of the toxin …
Ipomoeassin F binds Sec61α to inhibit protein translocation
Ipomoeassin F is a potent natural cytotoxin that inhibits growth of many tumor cell lines with
single-digit nanomolar potency. However, its biological and pharmacological properties …
single-digit nanomolar potency. However, its biological and pharmacological properties …
Skin and soft tissue infections due to nontuberculous mycobacteria
EA Misch, C Saddler, JM Davis - Current infectious disease reports, 2018 - Springer
Abstract Purpose of Review This review describes recent trends in the epidemiology of
nontuberculous mycobacteria (NTM), emerging pathogens, new insights into NTM …
nontuberculous mycobacteria (NTM), emerging pathogens, new insights into NTM …
Buruli ulcer, a prototype for ecosystem-related infection, caused by Mycobacterium ulcerans
D Zingue, A Bouam, RBD Tian… - Clinical microbiology …, 2018 - Am Soc Microbiol
Buruli ulcer is a noncontagious disabling cutaneous and subcutaneous mycobacteriosis
reported by 33 countries in Africa, Asia, Oceania, and South America. The causative agent …
reported by 33 countries in Africa, Asia, Oceania, and South America. The causative agent …
Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of …
J Ogbechi, BS Hall, T Sbarrato, J Taunton… - Cell death & …, 2018 - nature.com
Mycolactone is the exotoxin virulence factor of Mycobacterium ulcerans that causes the
neglected tropical disease Buruli ulcer. We recently showed it to be a broad spectrum …
neglected tropical disease Buruli ulcer. We recently showed it to be a broad spectrum …
Proteomics reveals scope of mycolactone-mediated Sec61 blockade and distinctive stress signature
Mycolactone is a bacteria-derived macrolide that blocks the biogenesis of a large array of
secretory and integral transmembrane proteins (TMP) through potent inhibition of the Sec61 …
secretory and integral transmembrane proteins (TMP) through potent inhibition of the Sec61 …