Interface engineering in multiphase systems toward synthetic cells and organelles: From soft matter fundamentals to biomedical applications

Z Liu, W Zhou, C Qi, T Kong - Advanced Materials, 2020 - Wiley Online Library
Synthetic cells have a major role in gaining insight into the complex biological processes of
living cells; they also give rise to a range of emerging applications from gene delivery to …

Advances in block copolymer-phospholipid hybrid vesicles: from physical-chemical properties to applications

E Brodszkij, B Städler - Chemical Science, 2024 - pubs.rsc.org
Hybrid vesicles, made of lipids and amphiphilic block copolymers, have become
increasingly popular thanks to their versatile properties that enable the construction of …

Constructing artificial respiratory chain in polymer compartments: Insights into the interplay between bo3 oxidase and the membrane

N Marušič, L Otrin, Z Zhao, RB Lira, FL Kyrilis… - Proceedings of the …, 2020 - pnas.org
Cytochrome bo 3 ubiquinol oxidase is a transmembrane protein, which oxidizes ubiquinone
and reduces oxygen, while pum** protons. Apart from its combination with F1Fo-ATPase …

Biodegradable hybrid block copolymer–lipid vesicles as potential drug delivery systems

S Khan, J McCabe, K Hill, PA Beales - Journal of Colloid and Interface …, 2020 - Elsevier
The anticipated benefits of nano-formulations for drug delivery are well known: for
nanomedicines to achieve this potential, new materials are required with predictive and …

Light‐driven ATP regeneration in diblock/grafted hybrid vesicles

C Kleineberg, C Wölfer, A Abbasnia, D Pischel… - …, 2020 - Wiley Online Library
Light‐driven ATP regeneration systems combining ATP synthase and bacteriorhodopsin
have been proposed as an energy supply in the field of synthetic biology. Energy is required …

En route to dynamic life processes by SNARE-mediated fusion of polymer and hybrid membranes

L Otrin, A Witkowska, N Marušič, Z Zhao, RB Lira… - Nature …, 2021 - nature.com
A variety of artificial cells springs from the functionalization of liposomes with proteins.
However, these models suffer from low durability without repair and replenishment …

Biomolecule–polymer hybrid compartments: combining the best of both worlds

CE Meyer, SL Abram, I Craciun… - Physical Chemistry …, 2020 - pubs.rsc.org
Compartmentalization is a fundamental principle in biology that is needed for the temporal
and spatial separation of chemically incompatible reactions and biomolecules. Nano-or …

PEO-b-PBD Diblock Copolymers Induce Packing Defects in Lipid/Hybrid Membranes and Improve Insertion Rates of Natively Folded Peptides

J Steinkuhler, ML Jacobs, MA Boyd… - …, 2022 - ACS Publications
Hybrid membranes assembled from biological lipids and synthetic polymers are a promising
scaffold for the reconstitution and utilization of membrane proteins. Recent observations …

Hybrid vesicular drug delivery systems for cancer therapeutics

M Mohammadi, S Taghavi, K Abnous… - Advanced Functional …, 2018 - Wiley Online Library
Nanoscale vesicles have provided a versatile platform for the transportation of various types
of anticancer and diagnostic agents. Vesicular carriers comprised of liposomes …

Membrane mixing and dynamics in hybrid POPC/poly (1, 2-butadiene-block-ethylene oxide)(PBd-b-PEO) lipid/block co-polymer giant vesicles

R Seneviratne, R Catania, M Rappolt, LJC Jeuken… - Soft Matter, 2022 - pubs.rsc.org
Lipids and block copolymers can individually self-assemble into vesicles, each with their
own particular benefits and limitations. Combining polymers with lipids allows for further …