The conversion of mechanical energy into biochemical changes within living cells is process
known as mechanotransduction. Bone is a quintessential tissue for studying the molecular …

Cell–cell and cell–matrix interactions mediated by cell adhesion molecules are important
mechanisms controlling cell fate and function. Here, we review recent advances in the …

Osteocytes, cells ensconced within mineralized bone matrix, are the primary skeletal
mechanosensors. Osteocytes sense mechanical cues by changes in fluid flow shear stress …

The primary cilium is a mechanosensor in a variety of mammalian cell types, initiating and
directing intracellular signaling cascades in response to external stimuli. When primary cilia …

Significance: Changes in shear stress associated with alterations in blood flow initiate a
signaling cascade that modulates the vascular phenotype. Shear stress is “sensed” by the …

Abstract Purpose of Review Osteocytes are the main mechanosensitive cells in bone.
Integrin-based adhesions have been shown to facilitate mechanotransduction, and therefore …

Cells respond in complex ways to their environment, making it challenging to predict a direct
relationship between the two. A key problem is the lack of informative representations of …

For individual cells in tissues to create the diverse forms of biological organisms, it is
necessary that they must reliably sense and generate the correct forces over the correct …

Highlights•Preferentially directing stem cell differentiation.•Positively influencing cell
function.•Favourably promoting cellular longevity.•Constructively enhancing extracellular …

As explained by Wolff's law and the mechanostat hypothesis, mechanical stimulation can be
used to promote bone formation. Low intensity pulsed ultrasound (LIPUS) is a source of …