Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …

The functions, purposes, and roles of metallothioneins have been the subject of
speculations since the discovery of the protein over 60 years ago. This article guides …

Copper is an essential micronutrient that plays a pivotal role in numerous physiological
processes in virtually all cell types. Nevertheless, the dysregulation of copper homeostasis …

Pyroptosis is increasingly considered a new weathervane in cancer immune therapy.
However, triggering specific pyroptotic tumor cell death while preserving normal cells still …

Copper dyshomeostasis is associated with a plethora of diseases, supporting the possibility
of applying copper ionophores to regenerate the metal homeostasis and treat copper …

The protein mediator of ERBB2-driven cell motility 1 (Memo1) is connected to many
signaling pathways that play key roles in cancer. Memo1 was recently postulated to bind …

Copper (Cu) is an essential micronutrient for most organisms and serves mainly as a redox-
active catalytic centre in enzymes cycling between Cu+ and Cu 2+. Membrane transporters …

The pathophysiology of ALS involves many signs of a disruption in copper homeostasis, with
both excess free levels and functional deficiency likely occurring simultaneously. This is …

Simple Summary Besides zinc, also iron and copper need to be considered to play a role in
the mode of action and resistance development of the anticancer thiosemicarbazone COTI-2 …

COTI-2 is a novel anticancer thiosemicarbazone in phase I clinical trial. However, the effects
of metal complexation (a main characteristic of thiosemicarbazones) and acquired …