Background The advent of new methods of male contraception would increase
contraceptive options for men and women and advance male contraceptive agency …

BACKGROUND Members of the cysteine-rich secretory proteins (CRISPS), antigen 5 (Ag5)
and pathogenesis-related 1 (Pr-1)(CAP) superfamily of proteins are found across the …

Mammalian sperm–egg adhesion depends on the trans-interaction between the sperm-
specific type I glycoprotein IZUMO1 and its oocyte-specific GPI-anchored receptor JUNO …

STUDY QUESTION What is the mechanism behind cryoinjury in human sperm, particularly
concerning the interplay between reactive oxygen species (ROS) and autophagy, and how …

Although gamete fusion represents the central event in sexual reproduction, the required
protein machinery is poorly defined. In sperm cells, Izumo1 and several Izumo1-associated …

Mitochondria-targeted antioxidants have great potential to counterbalance the generated
reactive oxygen species (ROS) because they cross the inner membrane of the mitochondria …

Convergence offers an opportunity to explore to what extent evolution can be predictable
when genomic composition and environmental triggers are similar. Here, we present an …

Introduction: Spermatozoa cryopreservation is an important technique to preserve fertility for
males. This study aimed at exploring the stability of epigenetics information in human …

In this study, the complexity of chromatin integrity was investigated in frozen‐thawed semen
samples from 37 sires with contrasting fertility, expressed as 56‐day non‐return rates …

Gamete membrane fusion is a critical cellular event in sexual reproduction. In addition, the
generation of knockout models has provided a powerful tool for testing the functional …