Taxol (paclitaxel), the most well-known taxane diterpenoid, is the best-selling natural-source
anticancer drug ever produced and one of the most common prescriptions in the treatment of …

Chiral nitrogen-containing compounds are widely distributed in nature and include many
biologically important molecules (Chart 1). In these compounds, the nitrogen-containing …

Abstract TAXOL1–4, a substance originally isolated from the Pacific yew tree (Taxus
brevifolia) more than two decades ago, has recently been approved for the clinical treatment …

The creation of uniformly molecular-sized through-pores within polymeric membranes and
the direct evidence of these pores are essential for fundamentally understanding the …

Taxol (a brand name for paclitaxel) is widely regarded as among the most famed natural
isolates ever discovered, and has been the subject of innumerable studies in both basic and …

All pharmaceutical products contain organic molecules; the source may be a natural product
or a fully synthetic molecule, or a combination of both. Thus, it follows that organic chemistry …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Numerous variations on structural motifs exist within pharmaceutical compounds that have
entered the clinic. These variations have amounted over many decades based on years of …

Covers all facets of the synthesis of ß-amino acids As evidenced by an exponential increase
in the literature published on the subject, interest in ß-amino acids has grown over the past …

An intramolecular Heck reaction (90→ 91) serves as the key step in the total synthesis of the
titled compounds. The synthetic route is based on utilizing the Wieland− Miescher ketone (5) …