Structure-based drug design (SBDD) has gained popularity owing to its ability to develop
more potent drugs compared to conventional drug-discovery methods. The success of …

Abstract Energy-coupling factor (ECF)-type transporters mediate the uptake of micronutrients
in many bacteria. They consist of a substrate-translocating subunit (S-component) and an …

Rational design of next-generation therapeutics can be facilitated by high-resolution
structures of drug targets bound to small-molecule inhibitors. However, application of …

Peripheral membrane proteins are temporarily coupled to the surface of a membrane,
penetrating into the lipid layer. In this work, it has been shown that the fraction of trans …

Cryo-electron microscopy (cryo-EM) has revolutionized structural biology by providing high-
resolution insights into biological macromolecules. Here, we present sub-3 Å resolution …

Entamoeba histolytica is an enteric protozoan parasite that causes human amebic colitis
and extraintestinal abscesses. As a prerequisite for parasite colonization and invasion …

Периферические мембранные белки временно связываются с поверхностью
мембраны, заглубляясь в липидный слой. В этой работе мы показываем, что в зоне …

In this thesis we mainly focus on membrane transporters that facilitate the transport of
vitamin B12 in bacteria. One of these transporters is the ABC transporters BacA from …

Batten disease or neuronal ceroid lipofuscinoses (NCL) is an inherited lysosomal storage
disorder caused by mutated genes referred to as CLNs (ceroid lipofuscinosis neuronal). One …

Ryanodine receptors (RyR) are intracellular ion channels that regulate Ca2+ flow from the
endoplasmic or sarcoplasmic reticulum (ER or SR) into the cytoplasm 180. Three isoforms of …