SERS nanoparticles in medicine: from label-free detection to spectroscopic tagging

LA Lane, X Qian, S Nie - Chemical reviews, 2015 - ACS Publications
The development of diagnostic and therapeutic nanoparticles for biomedical applications is
of broad current interest in science, engineering, and medicine. The fundamental basis is …

Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy

WB Dunn, DI Broadhurst, HJ Atherton… - Chemical society …, 2011 - pubs.rsc.org
The study of biological systems in a holistic manner (systems biology) is increasingly being
viewed as a necessity to provide qualitative and quantitative descriptions of the emergent …

Chemical Similarity Enrichment Analysis (ChemRICH) as alternative to biochemical pathway map** for metabolomic datasets

DK Barupal, O Fiehn - Scientific reports, 2017 - nature.com
Metabolomics answers a fundamental question in biology: How does metabolism respond to
genetic, environmental or phenotypic perturbations? Combining several metabolomics …

Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry

WB Dunn, D Broadhurst, P Begley, E Zelena… - Nature protocols, 2011 - nature.com
Metabolism has an essential role in biological systems. Identification and quantitation of the
compounds in the metabolome is defined as metabolic profiling, and it is applied to define …

[PDF][PDF] 'Omic'technologies: genomics, transcriptomics, proteomics and metabolomics.

RP Horgan, LC Kenny - Obstetrician & Gynaecologist, 2011 - researchgate.net
'Omic'technologies adopt a holistic view of the molecules that make up a cell, tissue or
organism. They are aimed primarily at the universal detection of genes (genomics), mRNA …

Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry

A Hirayama, K Kami, M Sugimoto, M Sugawara… - Cancer …, 2009 - aacrjournals.org
Most cancer cells predominantly produce energy by glycolysis rather than oxidative
phosphorylation via the tricarboxylic acid (TCA) cycle, even in the presence of an adequate …

Plasma free amino acid profiling of five types of cancer patients and its application for early detection

Y Miyagi, M Higashiyama, A Gochi, M Akaike… - PloS one, 2011 - journals.plos.org
Background Recently, rapid advances have been made in metabolomics-based, easy-to-
use early cancer detection methods using blood samples. Among metabolites, profiling of …

Clinical applications of metabolomics in oncology: a review

JL Spratlin, NJ Serkova, SG Eckhardt - Clinical cancer research, 2009 - aacrjournals.org
Metabolomics, an omic science in systems biology, is the global quantitative assessment of
endogenous metabolites within a biological system. Either individually or grouped as a …

Metabolomics-based methods for early disease diagnostics

GAN Gowda, S Zhang, H Gu, V Asiago… - Expert review of …, 2008 - Taylor & Francis
The emerging field of metabolomics, in which a large number of small-molecule metabolites
from body fluids or tissues are detected quantitatively in a single step, promises immense …

Chemometrics in metabolomics—a review in human disease diagnosis

R Madsen, T Lundstedt, J Trygg - Analytica chimica acta, 2010 - Elsevier
Metabolomics is a post genomic research field concerned with develo** methods for
analysis of low molecular weight compounds in biological systems, such as cells, organs or …