The actions of cannabis are mediated by receptors that are part of an endogenous
cannabinoid system. The endocannabinoid system (ECS) consists of the naturally occurring …

The human gut is a composite anaerobic environment with a large, diverse and dynamic
enteric microbiota, represented by more than 100 trillion microorganisms, including at least …

Arachidonoyl-glycerol (2-AG) and arachidonyl-ethanolamide (AEA) are endocannabinoids
that have been implicated in many physiologic disorders, including obesity, metabolic …

Inflammatory bowel disease (IBD) is a group of diseases characterized by inflammation of
the small and large intestine and primarily includes ulcerative colitis and Crohn's disease …

Abstract Background The IL23/Th17 pathway is essential for the onset of inflammatory bowel
disease (IBD), yet the specific mechanism by which this pathway initiates the disease …

Inflammatory bowel disease (IBD) is a general term used to describe a group of chronic
inflammatory conditions of the gastrointestinal tract of unknown etiology, including two …

Prodrug strategies have been proven to be a very effective way of addressing delivery
problems. Much of the chemistry in prodrug development relies on the ability to mask an …

The endocannabinoid system is up-regulated in numerous pathophysiological states such
as inflammatory, neurodegenerative, gastrointestinal, metabolic and cardiovascular …

The maintenance of intestinal homeostasis is fundamentally important to health. Intestinal
barrier function and immune regulation are key determinants of intestinal homeostasis and …

Background In ancient medicine, extracts of the marijuana plant Cannabis sativa were used
against diseases of the gastrointestinal (GI) tract. Today, our knowledge of the ingredients of …