Following pathogen infection or tissue damage, the stimulation of pattern recognition
receptors on the cell surface and in the cytoplasm of innate immune cells activates members …

Since the discovery of glucocorticoids in the 1940s and the recognition of their anti-
inflammatory effects, they have been amongst the most widely used and effective treatments …

Glucocorticoids are anti-inflammatory drugs that are widely used for the treatment of
numerous (autoimmune) inflammatory diseases. They exert their actions by binding to the …

Phosphatases are important regulators of intracellular signaling events, and their functions
have been implicated in many biological processes. Dual-specificity phosphatases …

Glucocorticoids are potent immunosuppressive agents with complex actions on immune
cells evoking the following effects: inducing apoptosis, changing differentiation fate …

It is well established that a family of dual-specificity MAP kinase phosphatases (MKPs) play
key roles in the regulated dephosphorylation and inactivation of MAP kinase isoforms in …

Glucocorticoids (GCs) are steroidal ligands for the GC receptor (GR), which can function as
a ligand-activated transcription factor. These steroidal ligands and derivatives thereof are …

Glucocorticoids (GCs) are steroid hormones produced by the adrenal gland and regulated
by the hypothalamus‐pituitary‐adrenal axis. GCs mediate effects that mostly result in …

Glucocorticoid hormones (GC) regulate essential physiological functions including energy
homeostasis, embryonic and postembryonic development, and the stress response. From …

Glucocorticoids have potent anti-inflammatory effects and have been used to treat patients
with rheumatoid arthritis for more than 60 years. However, severe adverse effects of …