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Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy
This article reviews and summarizes 200 years of Parkinson's disease. It comprises a
relevant history of Dr. James Parkinson's himself and what he described accurately and …
relevant history of Dr. James Parkinson's himself and what he described accurately and …
Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits?
Tremor in Parkinson's disease has several mysterious features. Clinically, tremor is seen in
only three out of four patients with Parkinson's disease, and tremor-dominant patients …
only three out of four patients with Parkinson's disease, and tremor-dominant patients …
The pathophysiology of essential tremor and Parkinson's tremor
We review recent evidence about the pathophysiology of essential tremor and tremor in
Parkinson's disease. We believe that a network perspective is necessary to understand this …
Parkinson's disease. We believe that a network perspective is necessary to understand this …
Alterations in neuronal activity in basal ganglia-thalamocortical circuits in the parkinsonian state
In patients with Parkinson's disease and in animal models of this disorder, neurons in the
basal ganglia and related regions in thalamus and cortex show changes that can be …
basal ganglia and related regions in thalamus and cortex show changes that can be …
Parkinsonian beta oscillations in the external globus pallidus and their relationship with subthalamic nucleus activity
Inappropriately synchronized beta (β) oscillations (15–30 Hz) in the subthalamic nucleus
(STN) accompany movement difficulties in idiopathic Parkinson's disease (PD). The cellular …
(STN) accompany movement difficulties in idiopathic Parkinson's disease (PD). The cellular …
Information processing, dimensionality reduction and reinforcement learning in the basal ganglia
Modeling of the basal ganglia has played a major role in our understanding of this elusive
group of nuclei. Models of the basal ganglia have undergone evolutionary and revolutionary …
group of nuclei. Models of the basal ganglia have undergone evolutionary and revolutionary …
A physiologically plausible model of action selection and oscillatory activity in the basal ganglia
The basal ganglia (BG) have long been implicated in both motor function and dysfunction. It
has been proposed that the BG form a centralized action selection circuit, resolving conflict …
has been proposed that the BG form a centralized action selection circuit, resolving conflict …
The cerebral network of Parkinson's tremor: an effective connectivity fMRI study
Parkinson's resting tremor has been linked to pathophysiological changes both in the basal
ganglia and in a cerebello-thalamo-cortical motor loop, but the role of those circuits in …
ganglia and in a cerebello-thalamo-cortical motor loop, but the role of those circuits in …
The external globus pallidus: progress and perspectives
DJ Hegeman, ES Hong… - European Journal of …, 2016 - Wiley Online Library
The external globus pallidus (GP e) of the basal ganglia is in a unique and powerful position
to influence processing of motor information by virtue of its widespread projections to all …
to influence processing of motor information by virtue of its widespread projections to all …
Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction
Dopaminergic dysregulation can cause motor dysfunction, but the mechanisms underlying
dopamine-related motor disorders remain under debate. We used an inducible and …
dopamine-related motor disorders remain under debate. We used an inducible and …