The struggle to end a millennia-long pandemic: novel candidate and repurposed drugs for the treatment of tuberculosis
BD Edwards, SK Field - Drugs, 2022 - Springer
This article provides an encompassing review of the current pipeline of putative and
developed treatments for tuberculosis, including multidrug-resistant strains. The review has …
developed treatments for tuberculosis, including multidrug-resistant strains. The review has …
[HTML][HTML] Progress report: Antimicrobial drug discovery in the resistance era
Antibiotic resistance continues to be a most serious threat to public health. This situation
demands that the scientific community increase their efforts for the discovery of alternative …
demands that the scientific community increase their efforts for the discovery of alternative …
Recent insight into the biological activities and SAR of quinolone derivatives as multifunctional scaffold
Quinolones are a type of bicyclic privileged building block with immense therapeutic
potential. They are known for their crucial role in modulating numerous diseases conditions …
potential. They are known for their crucial role in modulating numerous diseases conditions …
Design, synthesis, characterization, and anti-tubercular activity of novel ethyl-3-benzoyl-6, 8-difluoroindolizine-1-carboxylate analogues: molecular target identification …
P Mundhe, S Kidwai, SM Saini, HR Singh… - Journal of Molecular …, 2023 - Elsevier
A series of novel Ethyl-3-benzoyl-6, 8-difluoroindolizine-1-carboxylate analogues (4a-r)
were synthesized by reacting 3, 5-difluoropyridine, with phenacyl bromide to get quaternary …
were synthesized by reacting 3, 5-difluoropyridine, with phenacyl bromide to get quaternary …
Anti-tubercular activity and molecular docking studies of indolizine derivatives targeting mycobacterial InhA enzyme
Abstract A series of 1, 2, 3-trisubstituted indolizines (2a–2f, 3a–3d, and 4a–4c) were
screened for in vitro whole-cell anti-tubercular activity against the susceptible H37Rv and …
screened for in vitro whole-cell anti-tubercular activity against the susceptible H37Rv and …
In vitro anti-TB properties, in silico target validation, molecular docking and dynamics studies of substituted 1, 2, 4-oxadiazole analogues against Mycobacterium …
The alarming increase in multi-and extensively drug-resistant (MDR and XDR) strains of
Mycobacterium tuberculosis (MTB) has triggered the scientific community to search for …
Mycobacterium tuberculosis (MTB) has triggered the scientific community to search for …
Tuberculosis: an update on pathophysiology, molecular mechanisms of drug resistance, newer anti-TB drugs, treatment regimens and host-directed therapies
Human tuberculosis (TB) is primarily caused by Mycobacterium tuberculosis (Mtb) that
inhabits inside and amidst immune cells of the host with adapted physiology to regulate …
inhabits inside and amidst immune cells of the host with adapted physiology to regulate …
A review of the therapeutic importance of indole scaffold in drug discovery
Indole is known as a versatile heterocyclic building block for its multiple pharmacological
activities and has a high probability of success in the race for drug candidates. Many natural …
activities and has a high probability of success in the race for drug candidates. Many natural …
Design, synthesis and characterization of ethyl 3‐benzoyl‐7‐morpholinoindolizine‐1‐carboxylate as anti‐tubercular agents: In silico screening for possible target …
P Tiwari, GS Mangubhai, S Kidwai… - Chemical Biology & …, 2024 - Wiley Online Library
A thorough search for the development of innovative drugs to treat tuberculosis, especially
considering the urgent need to address develo** drug resistance, we report here a …
considering the urgent need to address develo** drug resistance, we report here a …
Drug re‐engineering and repurposing: A significant and rapid approach to tuberculosis drug discovery
The prevalence of tuberculosis (TB) remains the leading cause of death from a single
infectious agent, ranking it above all other contagious diseases. The problem to tackle this …
infectious agent, ranking it above all other contagious diseases. The problem to tackle this …