Organic fluorophores are indispensable tools in cells, tissue and in vivo imaging, and have
enabled much progress in the wide range of biological and biomedical fields. However …

Hybrid small-molecule/protein fluorescent probes are powerful tools for visualizing protein
localization and function in living cells. These hybrid probes are constructed by diverse site …

In the past 15 years, there have been rapid developments in the ability to cotranslationally
incorporate unnatural amino acids into proteins produced in cells, both at defined sites via …

Direct stochastic optical reconstruction microscopy (d STORM) uses conventional
fluorescent probes such as labeled antibodies or chemical tags for subdiffraction resolution …

Synergistic advances in optical physics, probe design, molecular biology, labeling
techniques and computational analysis have propelled fluorescence imaging into new …

The ability to measure dynamic changes in neurochemicals with high spatiotemporal
resolution is essential for understanding the diverse range of functions mediated by the …

Visualizing the structure and dynamics of biomolecules is critical to understand biological
function, and requires methods to fluorescently label targets of interest in their cellular …

Protein labeling approaches are important to study proteins in living cells, and genome
editing tools make it possible to tag endogenous proteins to address the concerns …

The spatiotemporal resolution of subdiffraction fluorescence imaging has been limited by the
difficulty of labeling proteins in cells with suitable fluorophores. Here we report a chemical …

The ability to specifically attach chemical probes to individual proteins represents a powerful
approach to the study and manipulation of protein function in living cells. It provides a …