Kidney stones (also known as urinary stones or nephrolithiasis) are highly prevalent,
affecting approximately 10% of adults worldwide, and the incidence of stone disease is …

Kidney stone disease (nephrolithiasis) is a common problem that can be associated with
alterations in urinary solute composition including hypercalciuria. Studies suggest that the …

Rationale: Identification of the specific cell types expressing CFTR (cystic fibrosis [CF]
transmembrane conductance regulator) is required for precision medicine therapies for CF …

Cystic fibrosis (CF) is a life-threatening autosomal-recessive disease caused by mutations in
a single gene encoding cystic fibrosis transmembrane conductance regulator (CFTR). CF …

The kidneys have a central role in the control of acid–base homeostasis owing to
bicarbonate reabsorption and production of ammonia and ammonium in the proximal tubule …

Background Primary distal renal tubular acidosis (dRTA) is a rare disorder, and we aimed to
gather data on treatment and long-term outcome. Methods We contacted paediatric and …

Cystic fibrosis (CF) is caused by defects in an anion channel, the cystic fibrosis
transmembrane conductance regulator (CFTR). Recently, a new airway epithelial cell type …

The kidney tubules provide homeostasis by maintaining the external milieu that is critical for
proper cellular function. Without homeostasis, there would be no heartbeat, no muscle …

The kidneys, by equilibrating the outputs to the inputs, are essential for maintaining the
constant volume, pH, and electrolyte composition of the internal milieu. Inability to do so …

Distal renal tubular acidosis (dRTA) is characterized by an impaired ability of the distal
tubule to excrete acid, leading to metabolic acidosis. Associated complications include bone …