Immunoneuropsychiatry—novel perspectives on brain disorders
Immune processes have a vital role in CNS homeostasis, resilience and brain reserve. Our
cognitive and social abilities rely on a highly sensitive and fine-tuned equilibrium of immune …
cognitive and social abilities rely on a highly sensitive and fine-tuned equilibrium of immune …
Restricting retrotransposons: a review
JL Goodier - Mobile DNA, 2016 - Springer
Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …
Human endogenous retroviruses in neurological diseases
The causes of multiple sclerosis and amyotrophic lateral sclerosis have long remained
elusive. A new category of pathogenic components, normally dormant within human …
elusive. A new category of pathogenic components, normally dormant within human …
Losing DNA methylation at repetitive elements and breaking bad
Background DNA methylation is an epigenetic chromatin mark that allows heterochromatin
formation and gene silencing. It has a fundamental role in preserving genome stability …
formation and gene silencing. It has a fundamental role in preserving genome stability …
Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling
Autoimmunity, gastrointestinal (GI) disorders and schizophrenia have been associated with
one another for a long time. This paper reviews these connections and provides a context by …
one another for a long time. This paper reviews these connections and provides a context by …
The developmental control of transposable elements and the evolution of higher species
M Friedli, D Trono - Annual review of cell and developmental …, 2015 - annualreviews.org
Transposable elements (TEs) account for at least 50% of the human genome. They
constitute essential motors of evolution through their ability to modify genomic architecture …
constitute essential motors of evolution through their ability to modify genomic architecture …
Telescope: Characterization of the retrotranscriptome by accurate estimation of transposable element expression
Characterization of Human Endogenous Retrovirus (HERV) expression within the
transcriptomic landscape using RNA-seq is complicated by uncertainty in fragment …
transcriptomic landscape using RNA-seq is complicated by uncertainty in fragment …
Patients with psychosis spectrum disorders hospitalized during the COVID-19 pandemic unravel overlooked SARS-CoV-2 past infection clustering with HERV-W ENV …
Epidemiology has repeatedly associated certain infections with a risk of further develo**
psychiatric diseases. Such infections can activate retro-transposable genetic elements …
psychiatric diseases. Such infections can activate retro-transposable genetic elements …
Learning from the past and looking to the future: emerging perspectives for improving the treatment of psychiatric disorders
Modern neuropsychopharmacology commenced in the 1950s with the serendipitous
discovery of first-generation antipsychotics and antidepressants which were therapeutically …
discovery of first-generation antipsychotics and antidepressants which were therapeutically …
Th17 pathway–mediated immunopathogenesis of schizophrenia: mechanisms and implications
Schizophrenia is a highly complex and severe neuropsychiatric disorder with an unknown
etiopathology. Evidence for a dysregulated immune system in both the risk for and …
etiopathology. Evidence for a dysregulated immune system in both the risk for and …