An optimally functional brain requires both excitatory and inhibitory inputs that are regulated
and balanced. A perturbation in the excitatory/inhibitory balance—as is the case in some …

Glutamate is the most abundant free amino acid in the brain and is at the crossroad between
multiple metabolic pathways. Considering this, it was a surprise to discover that glutamate …

l-Glutamate is the predominant excitatory neurotransmitter in the mammalian central
nervous system and plays important roles in a wide variety of brain functions, but it is also a …

Excitatory amino acid transporters (EAATs) encompass a class of five transporters with
distinct expression in neurons and glia of the central nervous system (CNS). EAATs are …

Neither normal brain function nor the pathological processes involved in neurological
diseases can be adequately understood without knowledge of the release, uptake and …

The astrocytic glutamate transporters excitatory amino acid transporters 1 and 2 (EAAT1 and
EAAT2) play a key role in nervous system function to maintain extracellular glutamate levels …

Extracellular concentrations of the predominant excitatory neurotransmitter, glutamate, and
related excitatory amino acids are maintained at relatively low levels to ensure an …

Traditionally, glutamate transporters have been viewed as membrane proteins that harness
the electrochemical gradient to slowly transport glutamate from the extracellular space into …

Glutamate neurotransmission and metabolism are finely modulated by the retinal network,
where the efficient processing of visual information is shaped by the differential distribution …

Glutamate is the predominant excitatory neurotransmitter in the central nervous system.
Excitatory amino acid transporter 2 (EAAT2) is primarily responsible for clearance of …