The occurrence of cancer entails a series of genetic mutations that favor uncontrollable
tumor growth. It is believed that various factors collectively contribute to cancer, and there is …

Highlights•The activity of writers and erasers of chromatin marks is coupled to the function of
reader modules.•Reader domains regulate recruitment, substrate specificity and catalysis of …

Transposable elements comprise roughly 40% of mammalian genomes. They have an
active role in genetic variation, adaptation and evolution through the duplication or deletion …

Chromatin modifications regulate genome function by recruiting proteins to the genome.
However, the protein composition at distinct chromatin modifications has yet to be fully …

The cyclin-dependent kinase 1 (Cdk1) drives cell division. To uncover additional functions of
Cdk1, we generated knockin mice expressing an analog-sensitive version of Cdk1 in place …

Overexpression of MYC is a hallmark of many human cancers. The MYC oncogene has long
been thought to execute its neoplastic functions by acting as a classic transcription factor …

Background Biomolecular condensates have been implicated in multiple cellular processes.
However, the global role played by condensates in 3D chromatin organization remains …

Recurrent mutations in histone-modifying enzymes imply key roles in tumorigenesis, yet
their functional relevance is largely unknown. Here, we show that JARID1B, encoding a …

ABSTRACT The enrichment of Enterotoxigenic Bacteroides fragilis (ETBF) has been
identified in CRC patients and associated with worse prognosis. Cancer stem cells (CSCs) …

Bivalent promoters in embryonic stem cells (ESCs) carry methylation marks on two lysine
residues, K4 and K27, in histone3 (H3). K4me2/3 is generally considered to promote …