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Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry
M Ishikawa, Y Hashimoto - Journal of medicinal chemistry, 2011 - ACS Publications
Aqueous solubility is essential for drug candidates. Poor aqueous solubility is likely to result
in poor absorption, even if the permeation rate is high, since the flux of a drug across the …
in poor absorption, even if the permeation rate is high, since the flux of a drug across the …
Alternative synthetic methods through new developments in catalysis by gold
Synthetic chemists are constantly challenged to consider more environmentally benign
methods for generation of the desired target molecules. 1 Recently, there has been an …
methods for generation of the desired target molecules. 1 Recently, there has been an …
Efficient selenium-integrated TADF OLEDs with reduced roll-off
Organic light emitters based on multiresonance-induced thermally activated delayed
fluorescent materials have great potential for realizing efficient, narrowband organic light …
fluorescent materials have great potential for realizing efficient, narrowband organic light …
Easy and fast prediction of green solvents for small molecule donor-based organic solar cells through machine learning
Solubility plays a critical role in many aspects of research (drugs to materials). Solubility
parameters are very useful for selecting appropriate solvents/non-solvents for various …
parameters are very useful for selecting appropriate solvents/non-solvents for various …
Synthesis, DFT studies, molecular docking and biological activity evaluation of thiazole-sulfonamide derivatives as potent Alzheimer's inhibitors
Alzheimer's disease is a major public brain condition that has resulted in many deaths, as
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
Solvent-induced sign inversion of circularly polarized luminescence: control of excimer chirality by hydrogen bonding
A series of pyrenes sandwiched by axially chiral 1, 1′-binaphthyls were synthesized.
Among them,(R, R)-3 possessing 2-hydroxy-3, 3′-dimethylbinaphthyls exhibited solvent …
Among them,(R, R)-3 possessing 2-hydroxy-3, 3′-dimethylbinaphthyls exhibited solvent …
Practical and General Alcohol Deoxygenation Protocol
Herein, we describe a practical protocol for the removal of alcohol functional groups through
reductive cleavage of their benzoate ester analogs. This transformation requires a strong …
reductive cleavage of their benzoate ester analogs. This transformation requires a strong …
Binaphthyl–bipyridyl cyclic dyads as a chiroptical switch
A series of chiral cyclic dyads, axially chiral binaphthyls linked to a 3, 3′-bipyridyl, was
synthesized. The dyad 2 bearing methoxy groups exhibited ON/OFF properties in circularly …
synthesized. The dyad 2 bearing methoxy groups exhibited ON/OFF properties in circularly …
Organocalcium-mediated nucleophilic alkylation of benzene
The electrophilic aromatic substitution of a C–H bond of benzene is one of the archetypal
transformations of organic chemistry. In contrast, the electron-rich π-system of benzene is …
transformations of organic chemistry. In contrast, the electron-rich π-system of benzene is …
Catalytic N2-to-NH3 Conversion by Fe at Lower Driving Force: A Proposed Role for Metallocene-Mediated PCET
We have recently reported on several Fe catalysts for N2-to-NH3 conversion that operate at
low temperature (− 78° C) and atmospheric pressure while relying on a very strong …
low temperature (− 78° C) and atmospheric pressure while relying on a very strong …