Abstract Gram-positive (G+) bacterial infection is a great burden to both healthcare and
community medical resources. As a result of the increasing prevalence of multidrug-resistant …

Endolysins are the lytic products of bacteriophages which play a specific role in the release
of phage progeny by degrading the peptidoglycan of the host bacterium. In the light of …

Staphylococcal biofilms are recognized as a significant problem in the food industry
because of their high resistance to antibiotics, and the use of bacteriophages or endolysins …

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most threatening
microorganisms for global human health. The current strategies to reduce the impact of S …

Endolysins, bacteriophage-encoded enzymes, have emerged as antibacterial agents that
can be actively applied in food processing systems as food preservatives to control …

Novel therapeutic strategies against difficult-to-treat bacterial infections are desperately
needed, and the faster and cheaper way to get them might be by repurposing existing …

The overuse and misuse of antibiotics in treating bacterial infections cause the rapid
emergence of drug-resistant bacteria, suggesting that the development of alternative …

Staphylococcus simulans lysostaphin cleaves pentaglycine cross-bridges between stem
peptides in the peptidoglycan of susceptible staphylococci, including S. aureus. This …

Here we show that the LysSA11 endolysin, derived from the virulent Staphylococcus aureus
phage SA11, has lytic activity against staphylococcal strains. Bioinformatics analysis …

Multi-drug resistance has called for a race to uncover alternatives to existing antibiotics.
Phage therapy is one of the explored alternatives, including the use of endolysins, which are …