NK cells for cancer immunotherapy
N Shimasaki, A Jain, D Campana - Nature reviews Drug discovery, 2020 - nature.com
Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …
associated with oncogenic transformation. This property, which is unique among immune …
Human NK cells: surface receptors, inhibitory checkpoints, and translational applications
NK cells play important roles in innate defenses against viruses and in the control of tumor
growth and metastasis. The regulation/induction of NK cell function is mediated by an array …
growth and metastasis. The regulation/induction of NK cell function is mediated by an array …
The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells
Natural killer (NK) cells kill infected, transformed and stressed cells when an activating NK
cell receptor is triggered. Most NK cells and some innate lymphoid cells express the …
cell receptor is triggered. Most NK cells and some innate lymphoid cells express the …
The molecular mechanism of natural killer cells function and its importance in cancer immunotherapy
S Paul, G Lal - Frontiers in immunology, 2017 - frontiersin.org
Natural killer (NK) cells are innate immune cells that show strong cytolytic function against
physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a …
physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a …
The natural cytotoxicity receptors in health and disease
The Natural Cytotoxicity Receptors (NCRs), NKp46, NKp44, and NKp30, were some of the
first human activating Natural Killer (NK) cell receptors involved in the non-MHC-restricted …
first human activating Natural Killer (NK) cell receptors involved in the non-MHC-restricted …
Killer Ig-like receptors (KIRs): their role in NK cell modulation and developments leading to their clinical exploitation
Natural killer (NK) cells contribute to the first line of defense against viruses and to the
control of tumor growth and metastasis spread. The discovery of HLA class I specific …
control of tumor growth and metastasis spread. The discovery of HLA class I specific …
[HTML][HTML] NK cells and ILCs in tumor immunotherapy
Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …
Multifunctional natural killer cell engagers targeting NKp46 trigger protective tumor immunity
L Gauthier, A Morel, N Anceriz, B Rossi… - Cell, 2019 - cell.com
Over the last decade, various new therapies have been developed to promote anti-tumor
immunity. Despite interesting clinical results in hematological malignancies, the …
immunity. Despite interesting clinical results in hematological malignancies, the …
Control of acute myeloid leukemia by a trifunctional NKp46-CD16a-NK cell engager targeting CD123
L Gauthier, A Virone-Oddos, J Beninga, B Rossi… - Nature …, 2023 - nature.com
CD123, the alpha chain of the IL-3 receptor, is an attractive target for acute myeloid
leukemia (AML) treatment. However, cytotoxic antibodies or T cell engagers targeting …
leukemia (AML) treatment. However, cytotoxic antibodies or T cell engagers targeting …
Natural killer cell engagers in cancer immunotherapy: next generation of immuno‐oncology treatments
O Demaria, L Gauthier, G Debroas… - European Journal of …, 2021 - Wiley Online Library
Immuno‐oncology is revolutionizing the treatment of cancers, by inducing the recognition
and elimination of tumor cells by the immune system. Recent advances have focused on …
and elimination of tumor cells by the immune system. Recent advances have focused on …