The epitranscriptome beyond m6A

D Wiener, S Schwartz - Nature Reviews Genetics, 2021 - nature.com
Following its transcription, RNA can be modified by> 170 chemically distinct types of
modifications—the epitranscriptome. In recent years, there have been substantial efforts to …

Detection technologies for RNA modifications

Y Zhang, L Lu, X Li - Experimental & molecular medicine, 2022 - nature.com
To date, more than 170 chemical modifications have been characterized in RNA, providing a
new layer of gene expression regulation termed the 'epitranscriptome'. RNA modification …

[HTML][HTML] RNA methylation and cancer treatment

B Yang, JQ Wang, Y Tan, R Yuan, ZS Chen… - Pharmacological …, 2021 - Elsevier
To this date, over 100 different types of RNA modification have been identified. Methylation
of different RNA species has emerged as a critical regulator of transcript expression. RNA …

Dynamic RNA modifications in gene expression regulation

IA Roundtree, ME Evans, T Pan, C He - Cell, 2017 - cell.com
Over 100 types of chemical modifications have been identified in cellular RNAs. While the
5′ cap modification and the poly (A) tail of eukaryotic mRNA play key roles in regulation …

[HTML][HTML] Acetylation of cytidine in mRNA promotes translation efficiency

D Arango, D Sturgill, N Alhusaini, AA Dillman, TJ Sweet… - Cell, 2018 - cell.com
Generation of the" epitranscriptome" through post-transcriptional ribonucleoside
modification embeds a layer of regulatory complexity into RNA structure and function. Here …

The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution

M Safra, A Sas-Chen, R Nir, R Winkler, A Nachshon… - Nature, 2017 - nature.com
Modifications on mRNA offer the potential of regulating mRNA fate post-transcriptionally.
Recent studies suggested the widespread presence of N 1-methyladenosine (m1A), which …

The RNA modification landscape in human disease

N Jonkhout, J Tran, MA Smith, N Schonrock, JS Mattick… - Rna, 2017 - rnajournal.cshlp.org
RNA modifications have been historically considered as fine-tuning chemo-structural
features of infrastructural RNAs, such as rRNAs, tRNAs, and snoRNAs. This view has …

Detecting RNA modifications in the epitranscriptome: predict and validate

M Helm, Y Motorin - Nature Reviews Genetics, 2017 - nature.com
RNA modifications are emerging players in the field of post-transcriptional regulation of
gene expression, and are attracting a comparable degree of research interest to DNA and …

The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA

D Dominissini, S Nachtergaele, S Moshitch-Moshkovitz… - Nature, 2016 - nature.com
Gene expression can be regulated post-transcriptionally through dynamic and reversible
RNA modifications. A recent noteworthy example is N 6-methyladenosine (m6A), which …

Modifications and functional genomics of human transfer RNA

T Pan - Cell research, 2018 - nature.com
Transfer RNA (tRNA) is present at tens of millions of transcripts in a human cell and is the
most abundant RNA in moles among all cellular RNAs. tRNA is also the most extensively …