The genetic basis of major depression
Major depressive disorder (MDD) is a common, debilitating, phenotypically heterogeneous
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …
A review of deep learning applications in human genomics using next-generation sequencing data
WS Alharbi, M Rashid - Human Genomics, 2022 - Springer
Genomics is advancing towards data-driven science. Through the advent of high-throughput
data generating technologies in human genomics, we are overwhelmed with the heap of …
data generating technologies in human genomics, we are overwhelmed with the heap of …
Reviewing the genetics of heterogeneity in depression: operationalizations, manifestations and etiologies
With progress in genome-wide association studies of depression, from identifying zero hits
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …
Applications of deep learning in understanding gene regulation
Gene regulation is a central topic in cell biology. Advances in omics technologies and the
accumulation of omics data have provided better opportunities for gene regulation studies …
accumulation of omics data have provided better opportunities for gene regulation studies …
Review of deep learning-based methods for non-destructive evaluation of agricultural products
Deep Learning (DL) has emerged as a pivotal modelling tool in various domains because of
its proficiency in learning distributed representations. Numerous DL algorithms have …
its proficiency in learning distributed representations. Numerous DL algorithms have …
Recent advances in artificial intelligence, mechanistic models, and speed breeding offer exciting opportunities for precise and accelerated genomics‐assisted …
Given the challenges of population growth and climate change, there is an urgent need to
expedite the development of high‐yielding stress‐tolerant crop cultivars. While traditional …
expedite the development of high‐yielding stress‐tolerant crop cultivars. While traditional …
What makes a good prediction? Feature importance and beginning to open the black box of machine learning in genetics
AM Musolf, ER Holzinger, JD Malley, JE Bailey-Wilson - Human Genetics, 2022 - Springer
Genetic data have become increasingly complex within the past decade, leading
researchers to pursue increasingly complex questions, such as those involving epistatic …
researchers to pursue increasingly complex questions, such as those involving epistatic …
DeepGAMI: deep biologically guided auxiliary learning for multimodal integration and imputation to improve genotype–phenotype prediction
Background Genotypes are strongly associated with disease phenotypes, particularly in
brain disorders. However, the molecular and cellular mechanisms behind this association …
brain disorders. However, the molecular and cellular mechanisms behind this association …
Autosomal sex-associated co-methylated regions predict biological sex from DNA methylation
Sex is a modulator of health that has been historically overlooked in biomedical research.
Recognizing this knowledge gap, funding agencies now mandate the inclusion of sex as a …
Recognizing this knowledge gap, funding agencies now mandate the inclusion of sex as a …
Map of epigenetic age acceleration: a worldwide analysis
We present a systematic analysis of epigenetic age acceleration based on by far the largest
collection of publicly available DNA methylation data for healthy samples (93 datasets, 23 K …
collection of publicly available DNA methylation data for healthy samples (93 datasets, 23 K …