The biogenesis, folding, and structure of α-helical membrane proteins (MPs) are important to
understand because they underlie virtually all physiological processes in cells including key …

The vast majority of proteins trafficking across or into the bacterial cytoplasmic membrane
occur via the translocon. The translocon consists of the SecYEG complex that forms an …

Recent research has provided an abundance of new information on membrane
biochemistry. Now more than ever, it is essential to update our current understanding of …

Membrane proteins destined for insertion into the inner membrane of bacteria or the
endoplasmic reticulum membrane in eukaryotic cells are synthesized by ribosomes bound …

A new computational approach to calculating binding energies and spatial positions of small
molecules, peptides, and proteins in the lipid bilayer has been developed. The method …

Numerous membrane proteins form multisubunit protein complexes, which contain both
integral and peripheral subunits, in addition to prosthetic groups. Bacterial membrane …

The elongation phase of protein synthesis defines the overall speed and fidelity of protein
synthesis and affects protein folding and targeting. The mechanisms of reactions taking …

Most membrane proteins are composed of hydrophobic α-helical transmembrane segments
and are integrated into the lipid bilayer of the endoplasmic reticulum by the highly conserved …

Several laboratories have carried out molecular dynamics (MD) simulations of arginine
interactions with lipid bilayers and found that the energetic cost of placing arginine in lipid …

Background Protein transporters translocate hydrophilic segments of polypeptide across
hydrophobic cell membranes. Two protein transporters are ubiquitous and date back to the …