Background White matter hyperintensities of presumed vascular origin (WMH) are one of the
imaging features of cerebral small vessel disease. Controversies persist about the effects of …

Post-stroke dementia (PSD) or post-stroke cognitive impairment (PSCI) may affect up to one
third of stroke survivors. Various definitions of PSCI and PSD have been described. We …

Objectives We aimed to objectify and compare persisting self‐reported symptoms in initially
hospitalized and non‐hospitalized patients after infection with severe acute respiratory …

The pathway leading from amyloid-β deposition to cognitive impairment is believed to be a
cornerstone of the pathogenesis of Alzheimer's disease (AD). However, what drives amyloid …

We report the case of a 79-year-old woman with Alzheimer's disease who participated in a
Phase III randomized controlled trial called CLARITY-AD testing the experimental drug …

Implementation of amyloid biomarkers in clinical practice would be accelerated if such
biomarkers could be measured in blood. We analyzed plasma levels of Aβ42 and Aβ40 in a …

White matter hyperintensities (WMHs) in the brain are the consequence of cerebral small
vessel disease, and can easily be detected on MRI. Over the past three decades, research …

We tested a newly described molecular memory system, CCR5 signaling, for its role in
recovery after stroke and traumatic brain injury (TBI). CCR5 is uniquely expressed in cortical …

Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features seen
on neuroimaging include recent small subcortical infarcts, lacunes, white matter …

Two decades of epidemiological research shows that silent cerebrovascular disease is
common and is associated with future risk for stroke and dementia. It is the most common …