In the field of antibiotherapy, intracellular infections remain difficult to eradicate mainly due to
the poor intracellular penetration of most of the commonly used antibiotics. Bacteria have …

Reflecting a complex set of interactions with its host, Salmonella spp. require multiple genes
for full virulence. Many of these genes are found inpathogenicity islands' in the chromosome …

As a result of an error during film output, Table 1 was published with some symbols missing.
The correct version can be found at http://www. sanger. ac. uk and is reproduced again here …

An insertional mutagenesis system that uses transposons carrying unique DNA sequence
tags was developed for the isolation of bacterial virulence genes. The tags from a mixed …

We have identified a region unique to the Salmonella typhimurium chromosome that is
essential for virulence in mice. This region harbors at least three genes: two (spiA and spiB) …

Salmonella typhimurium causes enteric and systemic disease by invading the intestinal
epithelium of the distal ileum, a process requiring the invasion genes of Salmonella …

Sigma factors provide promoter recognition specificity to RNA polymerase holoenzyme,
contribute to DNA strand separation, and then dissociate from the core enzyme following …

Bartonella spp. are facultative intracellular pathogens that employ a unique stealth infection
strategy comprising immune evasion and modulation, intimate interaction with nucleated …

Bacteria contain a remarkable RNA molecule—known alternatively as SsrA RNA, tmRNA, or
10Sa RNA—that acts both as a tRNA and as an mRNA to direct the modification of proteins …

New antibiotics are urgently needed to control infectious diseases. Metabolic enzymes could
represent attractive targets for such antibiotics, but in vivo target validation is largely lacking …